ZFIN ID: ZDB-FIG-140218-11
Spaich et al., 2012 - Fbxl22, A Cardiac-Enriched F-Box Protein, Regulates Sarcomeric Protein Turnover and is Essential for Maintenance of Contractile Function In Vivo. Circulation research   111(12):1504-1516 Full text @ Circ. Res.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibodies:
Fish:
Condition:
Knockdown Reagent:
Anatomical Term:
Stage: Long-pec
PHENOTYPE:
Fish:
Condition:
Knockdown Reagent:
Observed In:
Stage Range: Long-pec to Protruding-mouth

Fig. 8 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab-MF20 WB WT control Long-pec whole organism
WB WT + MO1-fbxl22 standard conditions Long-pec whole organism
Ab1-actn WB WT control Long-pec whole organism
WB WT chemical treatment: drug Long-pec whole organism
WB WT + MO1-fbxl22 chemical treatment: drug Long-pec whole organism
WB WT + MO1-fbxl22 standard conditions Long-pec whole organism
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-fbxl22 chemical treatment: drug Long-pec SCF-dependent proteasomal ubiquitin-dependent protein catabolic process decreased occurrence, abnormal
WT + MO1-fbxl22 standard conditions Long-pec cardiac muscle contraction decreased process quality, abnormal
Long-pec heart decreased contractility, abnormal
Long-pec heart edematous, abnormal
Long-pec SCF-dependent proteasomal ubiquitin-dependent protein catabolic process decreased occurrence, abnormal
Protruding-mouth cardiac muscle contraction decreased process quality, abnormal
Protruding-mouth heart decreased contractility, abnormal
Protruding-mouth heart edematous, abnormal
Full text @ Circ. Res.