FIGURE

Fig. 2

ID

ZDB-FIG-131210-23

Publication

Balow et al., 2013 - Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome

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Fig. 2

Zebrafish chd7 targeting results in CHARGE-like phenotypes. Whole-embryo lateral (A, C) and dorsal (B, D) views of representative Std control and chd7 morphant embryos at 4 dpf. The chd7 morphants display pectoral fin defects (E–F), eye abnormalities including under-developed or missing anterior eye structures (G–H), changes in otolith morphology (I–J), and pericardial edema (K–L). Missing or abnormal structures are highlighted with an asterisk (^N) and/or dashed line. Structures are also highlighted in Std morphants for comparison. HT=heart, L=lens, OT=otolith, PE=pericardial edema, PEC=pectoral fin, and R=retina.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO3-chd7
Knockdown Reagent:	MO3-chd7
Observed In:	blood circulation eye heart contraction otolith pectoral fin pericardium
Stage:	Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 382(1), Balow, S.A., Pierce, L.X., Zentner, G.E., Conrad, P.A., Davis, S., Sabaawy, H.E., McDermott, B.M., and Scacheri, P.C., Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome, 57-69, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.