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ZFIN ID: ZDB-FIG-130524-2
Ramos-Balderas et al., 2013 - The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype. BMC research notes   6:39 Full text @ BMC Res. Notes
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Day 5

Fig. 1 Dorsal views from five insertional zebrafish mutants in V-ATPase subunits. The fish larvae are shown at 2 dpf (A, C, E, G, I and K) and at 5 dpf (B, D, F, H, J and L). For each image a close up view is at the right side. Wild type larvae are in (A and B) and show normal pigmentation. Pigment dilution is observed in all V-ATPase mutants (CL), however the severity of the pigment phenotype was mild in V0-d1 (gene atp6vod1) (C and D) and V0-ac45b (gene atp6ap1b) (E and F). It was more severe in V1-E1b (gene atp6v1e1b) (G and H) and V1-H (gene atp6v1h) (I and J), but even more severe in V0-ca (gene atp6v0ca) (K and L). In all the mutants there are a combination of pale melanocytes and dark melanin spots considered to be fragments of cells. Pale melanocytes became scarce the more severe the phenotype was (compare C and I). Bars in low amplification views are 200 μm and bars in close ups are 20 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
atp6ap1bhi112Tg/hi112Tg standard conditions Long-pec melanocyte decreased pigmentation, abnormal
Long-pec melanocyte degenerate, abnormal
Day 5 melanocyte decreased pigmentation, abnormal
Day 5 melanocyte degenerate, abnormal
atp6v0cahi1207Tg/hi1207Tg standard conditions Long-pec melanocyte absent, abnormal
Day 5 melanocyte absent, abnormal
atp6v0d1hi2188bTg/hi2188bTg standard conditions Long-pec melanocyte decreased pigmentation, abnormal
Long-pec melanocyte degenerate, abnormal
Day 5 melanocyte decreased pigmentation, abnormal
Day 5 melanocyte degenerate, abnormal
atp6v1e1bhi577aTg/hi577aTg standard conditions Long-pec melanocyte decreased pigmentation, abnormal
Long-pec melanocyte degenerate, abnormal
Day 5 melanocyte decreased pigmentation, abnormal
Day 5 melanocyte degenerate, abnormal
atp6v1hhi923Tg/hi923Tg standard conditions Long-pec melanocyte absent, abnormal
Day 5 melanocyte absent, abnormal
Acknowledgments:
ZFIN wishes to thank the journal BMC research notes for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ BMC Res. Notes