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ZFIN ID: ZDB-FIG-121210-11
Littleton et al., 2012 - Whole Plant Based Treatment of Hypercholesterolemia with Crataegus laevigata in a Zebrafish Model. BMC Complementary & Alternative Medicine   12(1):105 Full text @ BMC Complement. Altern. Med.
Anatomical Term:
Stage: Days 21-29

Fig. 2 Hawthorn Leaves and Flowers (HLF) Decrease BODIPY-cholesterol fluorescence in 4%HCD-fed fish. A. Representative images of the vasculature of fish in 4%HCD and 4%HCD + HLF treated fish. Orange vasculature from TG(Kdrl:mCherry)/Casper line. Green is intravascular BOD-CH fluorescence B. Fluorescence output comparison between groups. Analyzed relative to mean of 4% HCD group having a value of 1. Significant difference between HLF and 4%HCD treated fish. * P < 0.05, bars are mean ± S.D. 1-way ANOVA, Holm-Sidak post-hoc multiple comparison. n = 15-17 per group. C. Comparison of percent uptake between untreated (control), CH-treated, and CH + HLF-treated diets. Five in each experimental group, with the experiment repeated 3x, showed similar uptake (P = 0.925, bars are mean ± S.D. of repeated experiments. 1-way ANOVA). D. Representative Images of BOD-CH treated and BOD-CH + Ezetimibe treated fish (4 dpf). E. Ezetimibe treatment decreases intravascular BOD-CH fluorescence (* P < 0.05, bars are mean ± S.D. 1-way ANOVA, Holm-Sidak post-hoc multiple comparison. n = 13-14 per group).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
mCherry mitfaw2/w2; mpv17a9/a9; s916Tg chemical treatment: pharmaceutical Days 21-29 vasculature IFL
Antibody Labeling Details No data available
Phenotype Details No data available
ZFIN wishes to thank the journal BMC Complementary & Alternative Medicine for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ BMC Complement. Altern. Med.