ZFIN ID: ZDB-FIG-121029-3
Ni et al., 2012 - Conditional control of gene function by an invertible gene trap in zebrafish. Proceedings of the National Academy of Sciences of the United States of America   109(38):15389-15394 Full text @ Proc. Natl. Acad. Sci. USA
Anatomical Term:
Stage: Days 21-29
Observed In:
Stage: Days 21-29

Fig. 5 Phenotype of liver-specific supv3l1 inactivation. (AD) Confocal images of the Left (A and B) and Right (C and D) sides of 21-d-old LiPan (A and C) and LiPan/supv3l1LKO (B and D) fish showing detached hepatocytes (white arrows) (B and D) and smaller right liver lobe (white arrow) in supv3l1LKO fish (D). (E and F) Histological analysis of wild-type (E) and supv3l1LKO (F) fish indicate disorganized liver with dead cells (arrowhead) but normal intestinal lumen (black arrows) in supv3l1LKO fish (F). (F) Survival curve of supv3l1LKO fish (lens YFP+) compared with supv3l1GtNf/GtNf siblings (lens YFP-) during the first 6 wk of life. One group was fed a larval diet until 28 dpf followed by a juvenile diet (red) and the other group was kept on the larval diet (blue). (G) Photograph of a wild-type and a supv3l1LKO mutant at 5 wk of age showing the smaller size of the mutant.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed gz15Tg standard conditions Days 21-29 liver IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
supv3l1vu497Gt/vu497Gt; gz15Tg; s955Tg standard conditions Days 21-29 hepatocyte detached from liver, abnormal
Days 21-29 hepatocyte disorganized, abnormal
Days 21-29 whole organism decreased size, abnormal
ZFIN wishes to thank the journal Proceedings of the National Academy of Sciences of the United States of America for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA