FIGURE

Fig. 3

ID

ZDB-FIG-120126-57

Publication

Lin et al., 2011 - Progenitor expansion in apc mutants is mediated by Jak/Stat signaling

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Fig. 3

Jak/Stat signaling mediates progenitor marker expression in the apc mutant hypothalamus. (A) Expression of ascl1b, a neural progenitor marker, is qualitatively increased in the apc mutant hypothalamus, and restored to wild-type levels by AG-490 treatment. Transverse cryosections at 36 hpf are shown. (B) Expression of Otx1/2, a hypothalamic progenitor marker, is increased in the apc mutant hypothalamus, and restored to wild-type levels by AG-490 treatment. Confocal projections from the ventral brain surface through the 36 hpf hypothalamus are shown. Otx1/2 immunohistochemistry is red, TO-PRO-3 nuclear stain is in blue. (C) The percent of Otx1/2+ cells is significantly increased in the apc mutant hypothalamus compared to wild-type siblings, and restored to wild-type levels by AG-490 treatment. Error bars = s.d., p < 0.05 by student′s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.