FIGURE

Fig. S3

ID

ZDB-FIG-110422-12

Publication

Kawahara et al., 2011 - Drug screening in a zebrafish model of Duchenne muscular dystrophy

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Fig. S3

Dystrophin morphant by injection of morpholino and the effects of candidate chemicals in recovering the phenotypes of the morphants. The dystrophin morphant has a similar phenotype to the sapje fish, which shows reduced birefringence and expression of dystrophin. (A, C, E, and F) WT. (B, D, G, and H) Dystrophin morphant. (A and B) Normal light image. (C and D) Birefringence image. (E and G) Immunostaining with anti-dystrophin antibody. (F and H) Immunostaining with anti-laminin antibody. (I) Percentage of dead affected and normal fish in morphants with treatment of each of the seven chemicals. In untreated dystrophin morphants, 30% are affected fish. For each chemical treatment, the percentage of affected fish is reduced compared with those of untreated morphants. Blue bar, normal. Red bar, affected fish. Yellow bar, dead fish (*P < 0.01, **P < 0.05; n = 3).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA