ZFIN ID: ZDB-FIG-110322-50
Veth et al., 2011 - Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma. PLoS Genetics   7(2):e1001310 Full text @ PLoS Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Condition:
Anatomical Term:
Stage Range: Days 45-89 to Adult
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage Range: Days 45-89 to Adult

Fig. 8

Expression of the gap43:GFP transgene in lrp2 mutants.

A–L Expression of the gap43:GFP transgene in flat-mounted retinas from 2-month bugeye heterozygotes (wild-type) (A–E) and homozygous mutants (F–J). Shown are 5 representative samples for each condition. Images capture a single plane of the nerve fiber layer using equal gain settings on a confocal microscope. Scale bar = 200 μm. Similar analysis on 6-month bugeye heterozygotes (wild-type) (K–O) and homozygous mutants (P–T). Note the stronger activation and unique wandering/circling phenotype in mutant axons.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP lrp2amw1/+; mil1Tg/+ surgical manipulation: cranial nerve II Days 45-89 retinal ganglion cell axon IFL
Adult retinal ganglion cell axon IFL
lrp2amw1/mw1; mil1Tg/+ surgical manipulation: cranial nerve II Days 45-89 retinal ganglion cell axon IFL
Adult retinal ganglion cell axon IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
lrp2amw1/mw1; mil1Tg/+ surgical manipulation: cranial nerve II Days 45-89 - Adult axon extension involved in regeneration disrupted, abnormal
Days 45-89 - Adult retinal ganglion cell axon circling, abnormal
Days 45-89 - Adult retinal ganglion cell axon disorganized, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.