ZFIN ID: ZDB-FIG-090424-1
Lai et al., 2009 - Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists   238(1):76-85 Full text @ Dev. Dyn.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Unknown to Adult

Fig. 3

Heterozygous fish from high-tumor rp mutant lines are growth-impaired. A: Outcrosses of each rp line were performed, and their progeny were weighed and genotyped at day 25. White bars represent the average weight (mg) of heterozygotes (het) whereas gray bars represent the average weight (mg) of the wild-type (WT) siblings for each rp line; error bars are ±2 SEM. The P value (unpaired t-test) between heterozygotes and wild-type siblings is indicated above each set of bars. Lines are ordered along the x-axis by decreasing incidence of zMPNSTs. B: The growth defect determined in A, represented as the ratio of average heterozygote weight to average wild-type weight (grey bars), compared with the frequency of zMPNSTs (black bars), as determined in Table 1. The most highly tumor-prone lines appear to be the most severely growth-impaired. *indicates a statistically significant difference (P < 0.01 by unpaired t-test). Lines are ordered along the x-axis the same as in A for ease of comparison.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
rpl13hi1016Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rpl14hi823Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rpl19hi1987Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
rpl23ahi2582Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
rpl28hi3893Tg/+ (AB/TU) standard conditions Days 21-29 whole organism decreased size, abnormal
rpl35hi258Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rpl36hi1807Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rpl36ahi10Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rpl7hi1061Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rps15hi2430Tg/+ (AB/TU) standard conditions Days 21-29 whole organism decreased size, abnormal
rps15ahi2649Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rps18hi1026Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
rps28hi3883Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rps3ahi1290Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rps7hi1034bTg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rps8ahi1974Tg/+ (AB/TU) standard conditions Unknown - Adult peripheral nervous system nerve neoplastic, abnormal
Days 21-29 whole organism decreased size, abnormal
rpsahi1479Tg/+ (AB/TU) standard conditions Days 21-29 whole organism decreased size, abnormal
Acknowledgments:
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