FIGURE

Fig. 5

ID

ZDB-FIG-070925-63

Publication

Albertson et al., 2007 - Fgf8 haploinsufficiency results in distinct craniofacial defects in adult zebrafish

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Fig. 5

Fig. 5. TRAP and AP activity is elevated in the jaws of ace^ti282a/+ zebrafish. A greater proportion of the lower jaw was TRAP positive in ace^ti282a/+ animals relative to homozygous wild-types siblings (A, B, F, F-ratio = 30.6, p < 0.001). Ace^ti282a/+ zebrafish also exhibited greater AP actively, localized to the anterior portion of the low jaw (C, D, G, F-ratio = 7.24, p = 0.01). The higher levels of both TRAP and AP activity observed in the mandibles of ace^ti282a/+ zebrafish are consistent with the occurrence of aberrant and ectopic bone formation (arrowhead and arrow, respectively, in panel E).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^ti282a/+
Observed In:	regulation of bone remodeling ventral mandibular arch
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 306(2), Albertson, R.C., and Yelick, P.C., Fgf8 haploinsufficiency results in distinct craniofacial defects in adult zebrafish, 505-515, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.