CRISPR

CRISPR1-hexb

ID

ZDB-CRISPR-200130-3

Name

CRISPR1-hexb

Previous Names

None

Target

hexb (1)

Sequence

5' - AACAGTCCACCGCCGGAC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
re04	hexb

Expression

Gene expression in Wild Types + CRISPR1-hexb

No data available

Phenotype

Phenotype resulting from CRISPR1-hexb

Phenotype	Fish	Figures
hexosaminidase activity decreased process quality, abnormal	WT + CRISPR1-hexb	Fig. 1 from Kuil et al., 2019
microglial cell lysosome increased size, abnormal	WT + CRISPR1-hexb	Fig. 1 from Kuil et al., 2019

Phenotype of all Fish created by or utilizing CRISPR1-hexb

Phenotype	Fish	Conditions	Figures
head hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
spleen hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
brain hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
brain apoptotic, abnormal	hexb^re04/re04	standard conditions	Fig. 4 from Kuil et al., 2019
brain oligosaccharide increased amount, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
pancreas oligosaccharide increased amount, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
microglial cell lysosome morphology, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
liver oligosaccharide increased amount, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
pancreas hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
gonad hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
gonad oligosaccharide increased amount, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
liver hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
locomotion decreased occurrence, abnormal	hexb^re04/re04	standard conditions	Fig. 4 from Kuil et al., 2019
intestine oligosaccharide increased amount, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
spleen oligosaccharide increased amount, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
intestine hexosaminidase activity decreased process quality, abnormal	hexb^re04/re04	standard conditions	Fig. 2 from Kuil et al., 2019
microglial cell lysosome increased size, abnormal	WT + CRISPR1-hexb	standard conditions	Fig. 1 from Kuil et al., 2019
hexosaminidase activity decreased process quality, abnormal	WT + CRISPR1-hexb	standard conditions	Fig. 1 from Kuil et al., 2019

Citations