ZFIN ID: ZDB-GENE-030131-2333
Gene Name: hexosaminidase B (beta polypeptide)
Gene Symbol: hexb
Previous Names: hexa, fc04h11, si:dkey-35i22.2, wu:fc04h11, wu:fv09f06
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Targeting reagents: MO1-hexb (1), MO2-hexb (1)
PHENOTYPE
Data: Fig. S4a from KalĂ©n et al., 2009
Observed in: blood circulation, blood vasculature, cell death, extension (all 9) expand
DISEASE ASSOCIATED WITH hexb HUMAN ORTHOLOG 
Disease Ontology Term OMIM Term OMIM Phenotype ID
Sandhoff disease Sandhoff disease, infantile, juvenile, and adult forms 268800
GENE ONTOLOGY 
Ontology GO Term
Biological Process angiogenesis (more)
Molecular Function beta-N-acetylhexosaminidase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013781 (1)
  • InterPro:IPR015883 (1)
  • InterPro:IPR017853 (1)
  • InterPro:IPR025705 (1)
  • InterPro:IPR029018 (1)
  • InterPro:IPR029019 (1)
  • Pfam:PF00728 (1)
  • Pfam:PF14845 (1)
  • EC:3.2.1.52 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hexb-001 (1) 2024
    hexb-002 (1) 1642
    hexb-003 (1) 955
    ncRNA hexb-004 (1) 928
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hexb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    hexbContained in: [BAC] CH73-198E16 (1) (order this), DKEY-35I22 (1) (order this)
    hexbEncodes: [EST] fc04h11, fv09f06
    [cDNA] MGC:162596 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114845 (1) 2395bp
    Genomic GenBank:BX571730 160875bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IQN2 (1) 542aa
    Sequence Clusters UniGene:5384 (1)
    Sequence Information (all 27)
    OTHER hexb GENE PAGES 
  • Gene:323613 (1)
  • VEGA:OTTDARG00000032626 (1)
  • Ensembl(GRCz10):ENSDARG00000034368 (1)
  • ORTHOLOGY for hexb (Chr: 5) 
    Species Symbol Chromosome Accession # Evidence
    Human HEXB 5
  • Gene:3074
  • OMIM:606873
  • HGNC:4879
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Hexb 13
  • MGI:96074
  • Gene:15212
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    Orthology Note
    Woods, et al. (2005. Genome Res. 15:1307-1314.) reported this gene as hexa with orthology to human HEXA based on amino acid similarity. Subsequent analysis suggests this gene is hexb with orthology to human HEXB and mouse Hexb based on amino acid similarity and conserved location.
    CITATIONS (16)