ZFIN ID: ZDB-GENE-030131-2333
Gene Name: hexosaminidase B (beta polypeptide)
Gene Symbol: hexb    Nomenclature History

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Previous Names: hexa, fc04h11, si:dkey-35i22.2, wu:fc04h11, wu:fv09f06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have N-acetyl-beta-D-galactosaminidase activity and beta-N-acetylhexosaminidase activity. Involved in angiogenesis. Human ortholog(s) of this gene implicated in Sandhoff disease and spinal muscular atrophy. Orthologous to human HEXB (hexosaminidase subunit beta).
Genome Resources: Alliance (1),  Gene:323613 (1),  Ensembl(GRCz11):ENSDARG00000034368 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
re04 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-hexb 1
MO1-hexb N/A 1
MO2-hexb N/A 1
DISEASE ASSOCIATED WITH hexb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sandhoff disease Alliance Sandhoff disease, infantile, juvenile, and adult forms 268800
DISEASE ASSOCIATED WITH hexb VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
lysosomal storage disease hexbre04/re04 standard conditions Kuil et al., 2019
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Molecular Function hexosaminidase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hexb-201 (1)    Ensembl 2024
hexb-202 (1)    Ensembl 1642
hexb-203 (1)    Ensembl 955
ncRNA hexb-004 (1) 928
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hexb No data available
MARKER RELATIONSHIPS
hexb Contained in: [BAC] CH73-198E16 (1), DKEY-35I22 (1) (order this)
hexb Encodes: [EST] fc04h11, fv09f06
[cDNA] MGC:162596 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001114845 (1)
Genomic GenBank:BX571730 160875 nt
Select Tool
Polypeptide UniProtKB:A2BHD8 (1) 541 aa
Sequence Information (all 26)
ORTHOLOGY for hexb ( Chr: 5 )
CITATIONS (26)