Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-2333
Gene Name: hexosaminidase B (beta polypeptide)
Gene Symbol: hexb
Previous Names: hexa, fc04h11, si:dkey-35i22.2, wu:fc04h11, wu:fv09f06
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION No data available
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-hexb (1), MO2-hexb (1)
PHENOTYPE
Data: Fig. S4a from KalĂ©n et al., 2009
Observed in: blood circulation, blood vasculature, cell death, extension (all 9) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Sandhoff disease, infantile, juvenile, and adult forms 268800
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Molecular Function beta-N-acetylhexosaminidase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013781 (1)
  • InterPro:IPR015883 (1)
  • InterPro:IPR017853 (1)
  • InterPro:IPR025705 (1)
  • InterPro:IPR029018 (1)
  • InterPro:IPR029019 (1)
  • Pfam:PF00728 (1)
  • Pfam:PF14845 (1)
  • EC:3.2.1.52 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hexb-001 (1) 2024
    hexb-002 (1) 1642
    hexb-003 (1) 955
    ncRNA hexb-004 (1) 928
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hexb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hexb Contained in: [BAC] CH73-198E16 (1) (order this), DKEY-35I22 (1)
    hexb Encodes: [EST] fc04h11, fv09f06
    [cDNA] MGC:162596 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114845 (1) 2395 bp
    Genomic GenBank:BX571730 160875 bp
    Select Tool
    Polypeptide UniProtKB:A2BHD8 (1) 541 aa
    Sequence Clusters UniGene:5384 (1)
    Sequence Information (all 24)
    OTHER hexb GENE PAGES
  • Gene:323613 (1)
  • VEGA:OTTDARG00000032626 (1)
  • Ensembl(Zv9):ENSDARG00000034368 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish hexb 5  
    Human HEXB 5 (5q13)
  • OMIM:606873
  • Gene:3074
  • Mouse Hexb 13 ( 50.66 cM)
  • MGI:96074
  • Gene:15212
  • Orthology Details
    Orthology Note
    CITATIONS (15)