Genomic Feature
fh258
- ID
- ZDB-ALT-071015-5
- Name
- fh258
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Moens Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 9288844 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>A at position 429 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Tyr>Stop at position 143 (1)
- Flanking Sequence
-
CTCAGTCAAGTTTTTTATGAACTCCCAGTGGAGTTCACATTTGGGGGGGGGGGCGAAAAACAAACATCGATGAAGCTCTTTAATTCCTCCATCCGTTTTTTTTTTCTTCAGGCGAGGAGCTTTTTGGCCTGCAGCTCCATTTCGGCAGCCCTCTTCAGCGCTACGTCAACCAGCAGCTGGAAACCGCTGAAGTCCTGGGTGAGGTCGGGTGGGGTGGGCGGAGGGGTGTTGAACAGGCCGCTCTGAGGGCTGACGTTACCCTCCCCTCGACACCCGAATAGGCTGGCCGCATCTGTGAGTGGCAGCTCTGTGGCTCCCTCGACGCCGAGGCGCGTTGTTGTGTTGATGCCTTGCGTGGCTGTGGTGATAGTGGTGTGGCAGATGACGGAGGGTCTGGGTAAGACAGGTCCGGGCGAGGGAGGTGTTTTAGGGGACAGGGCCTTTTTGGGGTAACCGTTGGAAGTGGGTGTGTTGCTGGTCGGGTGAGGTGAGCCAGGCTC
G/T TAGCTGTTGCGGTCTTCTCCGTTGGCGAGCAGACCGTGTTTCGGGGACTGGGAGTTGTCACTGAGCATTTCGCCACCCTTGCTGCCCCGCCGCGAGATGGTGAACTGGTTGGGGTCCTTGCCATCTTTCCGGAGCATCTCAGGAAGGAGTCGTCGCCGCGCATTTATAAACCAGTTGCAAACCTGTGGAGAGATACAGATACAATGATTATTGATACAATCCAATTTTTACTATTATTACATTTATTGTGTACTACAATCCCCAAATAATTAGCTGTAGCTTTTAAGATTGTTTGTTTAAAACTGTAAAAGCATTGTTAATGTTTGTTTAAAACTAAAAACATTAACACTAAAATTACTGAGAACAGAACAAAAACAACATTGATTAAAAGCTAAAATCATTTATGAAATAAACTTCAATAGTACTTGATGCTAAAATAACCAGTCTTTTAACATAGAAATGCTTGTCTTGTGTTATGTTCAATTGTCGAGAAAATTACA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tgif1fh258/fh258 | Homozygous | ♀+/- ♂+/- | Fig. 4 from Lenkowski et al., 2013 | 2 figures from Lenkowski et al., 2013 | |
| tgif1fh258/fh258 | Homozygous | Unknown | Fig. 6  from Taylor et al., 2019 | Fig. 6 from Taylor et al., 2019 | |
| tgif1fh258/+ (AB) | Heterozygous | Unknown | |||
| tgif1fh258/fh258; mi2002Tg | Complex | 3 figures from Lenkowski et al., 2013 | 3 figures from Lenkowski et al., 2013 | ||
| tgif1fh258/fh258 + MO2-mir18a | Complex | Fig. 6 from Taylor et al., 2019 | |||
| six3bvu87/vu87; tgif1fh258/fh258; mi2002Tg | Complex | Fig. 6 from Lenkowski et al., 2013 | Fig. 6 from Lenkowski et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Taylor, S.M., Giuffre, E., Moseley, P., Hitchcock, P.F. (2019) The microRNA, miR-18a, regulates NeuroD and photoreceptor differentiation in the retina of the zebrafish. Developmental Neurobiology. 79(2):202-219
- Lenkowski, J.R., Qin, Z., Sifuentes, C.J., Thummel, R., Soto, C.M., Moens, C.B., Raymond, P.A.. (2013) Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling. Glia. 61(10):1687-1697
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