Genomic Feature
hi3174aTg
- ID
- ZDB-ALT-040826-6
- Name
- hi3174aTg
- Synonyms
-
- hi3174a (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 1: 25651347 - 25651348 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| plrg1hi3174aTg/hi3174aTg | Homozygous | Unknown | text only from Amsterdam et al., 2004 | Fig. 5  from Sorrells et al., 2012 | |
| plrg1hi3174aTg/+ (AB) | Heterozygous | Unknown | |||
| plrg1hi3174aTg/+ (AB/TU) | Heterozygous | Unknown | |||
| plrg1hi3174aTg | Unknown | Unknown | Fig. for (hi3174a) from Phenotype Annotation (1994-2006) | ||
| plrg1hi3174aTg (AB) | Unknown | Unknown | Fig. 2 from Sorrells et al., 2018 | ||
| tp53zdf1/zdf1; plrg1hi3174aTg (AB) | Complex |
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Supplemental Information
- Genotyping protocol
- hi3174atg.pdf
- Casey, M.J., Call, A.M., Thorpe, A.V., Jette, C.A., Engel, M.E., Stewart, R.A. (2022) The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis. iScience. 26:105737105737
- Sorrells, S., Nik, S., Casey, M., Cameron, R.C., Truong, H., Toruno, C., Gulfo, M., Lowe, A., Jette, C., Stewart, R.A., Bowman, T.V. (2018) Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms. 11(2)
- Sorrells, S., Carbonneau, S., Harrington, E., Chen, A.T., Hast, B., Milash, B., Pyati, U., Major, M.B., Zhou, Y., Zon, L.I., Stewart, R.A., Look, A.T., and Jette, C. (2012) Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53. PLoS Genetics. 8(8):e1002922
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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