ZFIN ID: ZDB-GENE-040426-2787
Gene Name: pleiotropic regulator 1
Gene Symbol: plrg1    Nomenclature History

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Previous Names: wu:fi74f01, zgc:55651, zgc:86603

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator and negative regulation of apoptotic process. Predicted to colocalize with DNA replication factor A complex. Orthologous to human PLRG1 (pleiotropic regulator 1).
Genome Resources: Alliance (1),  Gene:100004402 (1),  Ensembl(GRCz11):ENSDARG00000037283 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7138004]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1902Tg Transgenic Insertion Intron 2 Unknown DNA
hi3174aTg Transgenic Insertion Exon 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13503 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24845 Point Mutation Unknown Premature Stop ENU
    sa38266 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko487a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko487b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-plrg1 1
    MO1-plrg1 N/A 3
    DISEASE ASSOCIATED WITH plrg1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH plrg1 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plrg1-201 (1)    Ensembl 2192
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plrg1 No data available
    MARKER RELATIONSHIPS
    plrg1 Contained in: [BAC] DKEY-30K22 (1) (order this)
    plrg1 Encodes: [EST] fi74f01 (1), IMAGE:7138004 (1)
    [cDNA] MGC:55651 (1), MGC:86603 (1), MGC:174842 (1), MGC:191623 (1), MGC:198378 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213440 (1) 2163 nt
    Genomic GenBank:AL935184 (1) 255909 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5U3B5 (1) 511 aa
    Sequence Information (all 36)
    ORTHOLOGY for plrg1 ( Chr: 1 )
    CITATIONS (29)