Figure 1.

The chemical structure of 22 compounds evaluated for anti-melanogenic activity.
Figure 2.

Docking results of compound Q1-Q12 with tyrosinase. Green dotted line represents hydrogen bond, light pink dotted line represents hydrophobic interaction, grey dotted line represents electrostatic interaction, the pink dotted line represents the π–π interaction, the purple dotted line represents the π–σ interaction, the red dotted line indicates unfavourable factors.
Figure 3.

The structure-activity relationship (SAR) of mushroom tyrosinase inhibitors. “↑” indicates enhanced inhibitory effect, “↓” denotes reduced inhibitory effect.
Figure 4.

(A) the bar chart of melanin signal intensity in zebrafish head, (B) the whitening efficacies of zebrafish at different concentrations, (C) the results of inhibition of melanin formation in zebrafish by some compounds. Compared with the normal control group, * p < 0.05, ** p < 0.01, *** p < 0.001, statistical analysis p < 0.05, efficacy value ≥ 20%, judged to be effective.
Figure 5.

A: the bar chart of melanin signal intensity in zebrafish head, B: the whitening efficacies of zebrafish at different concentrations. Compared with the normal control group, *p < 0.05, **p < 0.01, ***p < 0.001, statistical analysis p < 0.05, efficacy value ≥ 20%, judged to be effective.
Figure 6.

The structure-activity relationship (SAR) of anti-melanogenic compounds. 1: (A) the most potent compounds; (B) moderately to highly effective ones. 2: “↑” indicates enhanced inhibitory effect, “↓” denotes reduced inhibitory effect, “*” represents no significant change in inhibitory activity.
Figure 7.

The possible mechanisms of inhibiting melanin synthesis.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Enzyme Inhib Med Chem
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