PUBLICATION
2,5-Dihydroxyphenylethanone: an anti-melanogenic bioactive compound isolated from Ganoderma cochlear
- Authors
- Ning, M., Liu, X.C., He, M., Peng, X.R., Qiu, M.H.
- ID
- ZDB-PUB-250430-14
- Date
- 2025
- Source
- Journal of enzyme inhibition and medicinal chemistry 40: 24953642495364 (Journal)
- Registered Authors
- Keywords
- 2,5-dihydroxyacetophenone, Ganoderma cochlear, anti-melanogenesis, chemical synthesis, zebrafish
- MeSH Terms
-
- Dose-Response Relationship, Drug
- Animals
- Acetophenones*/chemistry
- Acetophenones*/isolation & purification
- Acetophenones*/pharmacology
- Molecular Structure
- Structure-Activity Relationship
- Zebrafish
- Ganoderma*/chemistry
- Melanins*/antagonists & inhibitors
- Melanins*/biosynthesis
- PubMed
- 40302176 Full text @ J Enzyme Inhib Med Chem
Citation
Ning, M., Liu, X.C., He, M., Peng, X.R., Qiu, M.H. (2025) 2,5-Dihydroxyphenylethanone: an anti-melanogenic bioactive compound isolated from Ganoderma cochlear. Journal of enzyme inhibition and medicinal chemistry. 40:24953642495364.
Abstract
2,5-dihydroxyacetophenone, a natural product from the fruiting bodies of Ganoderma cochlear, can effectively and safely inhibit the production of melanin in zebrafish model. To achieve analogues with more significant inhibition, 9 analogs were synthesised and 13 analogues were purchased commercially. Among them, 14 compounds can inhibit melanin production, of which 5 compounds displayed the most significant inhibitory effects, with inhibitory rates of more than 80%, compared to positive control SymWhite®377 (phenylethyl resorcinol). This study elucidated the melanin-inhibitory effects of 2,5-dihydroxyacetophenone and its analogs, providing a theoretical foundation for their potential applications in anti-melanogenic reagents.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping