FIGURE SUMMARY
Title

Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders

Authors
Mhalhel, K., Sicari, M., Pansera, L., Chen, J., Levanti, M., Diotel, N., Rastegar, S., Germanà, A., Montalbano, G.
Source
Full text @ Cells

Basic skeleton structure of flavonoids and its subclasses. Adapted with permission from [38]. 2021, Giuseppe Montalbano.

The different biological processes involved in the development of neurodegenerative diseases.

Schematic drawing of (A) a sagittal section of rodent (left), zebrafish (middle), and human (right) brains with the main neurogenic niches indicated in red. The mammalian brain displays only two main neurogenic niches: the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus. The black lines correspond to coronal sections. (B,C): Transversal sections through the brain, marking the major neurogenic niches of the respective species shown in A. In zebrafish, the red dots correspond to slow-cycling progenitors (mainly radial glial cells, type 2), and the green ones to fast-cycling progenitors (mainly neuroblasts, type 3). OB, olfactory bulbs; Ce, cerebellum; D, telencephalic dorsal area; Hyp, hypothalamus; RMS, rostral migratory stream; Dm, dorsomedial zone of the dorsal telencephalon; Dc, central zone of the dorsal telencephalon; Dl, lateral zone of the dorsal telencephalon; Dp, posterior zone of the dorsal telencephalon; Vd, dorsal nucleus of the ventral telencephalon; Vv, ventral nucleus of the ventral telencephalon. This figure is adapted from [296,297].

Acknowledgments
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