PUBLICATION
Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders
- Authors
- Mhalhel, K., Sicari, M., Pansera, L., Chen, J., Levanti, M., Diotel, N., Rastegar, S., Germanà, A., Montalbano, G.
- ID
- ZDB-PUB-230122-15
- Date
- 2023
- Source
- Cells 12(2): (Review)
- Registered Authors
- Chen, Jincan, Germanà, Antonino, Mhalhel, Kamel, Montalbano, Giuseppe, Rastegar, Sepand
- Keywords
- Alzheimer, antioxidant, brain, flavonoids, neurodegeneration, neurogenesis, neuroinflammation, neuropathology, neuroplasticity, zebrafish
- MeSH Terms
-
- Animals
- Brain/metabolism
- Flavonoids/pharmacology
- Flavonoids/therapeutic use
- Humans
- Neurodegenerative Diseases*/drug therapy
- Neurodegenerative Diseases*/metabolism
- Parkinson Disease*/metabolism
- Zebrafish/metabolism
- PubMed
- 36672187 Full text @ Cells
Citation
Mhalhel, K., Sicari, M., Pansera, L., Chen, J., Levanti, M., Diotel, N., Rastegar, S., Germanà, A., Montalbano, G. (2023) Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders. Cells. 12(2):.
Abstract
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and memory. Moreover, flavonoids are known to impact the biological processes involved in developing neurodegenerative diseases, namely oxidative stress, neuroinflammation, and mitochondrial dysfunction. Thus, several flavonoids could be used as adjuvants to prevent and counteract neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Zebrafish is an interesting model organism that can offer new opportunities to study the beneficial effects of flavonoids on neurodegenerative diseases. Indeed, the high genome homology of 70% to humans, the brain organization largely similar to the human brain as well as the similar neuroanatomical and neurochemical processes, and the high neurogenic activity maintained in the adult brain makes zebrafish a valuable model for the study of human neurodegenerative diseases and deciphering the impact of flavonoids on those disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping