- Title
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MPTP-Treated Zebrafish Recapitulate 'Late-Stage' Parkinson's-like Cognitive Decline
- Authors
- Bashirzade, A.A.O., Cheresiz, S.V., Belova, A.S., Drobkov, A.V., Korotaeva, A.D., Azizi-Arani, S., Azimirad, A., Odle, E., Gild, E.V., Ardashov, O.V., Volcho, K.P., Bozhko, D.V., Myrov, V.O., Kolchanova, S.M., Polovian, A.I., Galumov, G.K., Salakhutdinov, N.F., Amstislavskaya, T.G., Kalueff, A.V.
- Source
- Full text @ Toxics
Schematic representation of Y maze apparatus, as in [30], with minor modifications. Removable arms were constantly swapped around. |
LD50 values calculated using the linear regression of the constructed curves, based on the graphical method of Miller and Tainter in the Excel software. |
Analysis of cognitive functions in adult zebrafish in the aquatic Y-maze test (panel (A), assessed as % of spontaneous alternation behavior, SAB, n = 9–19 per group, analyzed using the unpaired two-sample t-test and Pearson correlation (Panel (B)) and the inhibitory avoidance test (IAT, n = 9–19 per group, panel (C), analyzed using paired sample t-test). Data are presented as the violin and dot plots. Red dots with lines represent mean ± SD; * p < 0.05 vs. control fish, unpaired two-sample t-test, # p < 0.05 vs. control day 1, paired t-test. PHENOTYPE:
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Artificial intelligence (AI)-based convolution neural network (CNN) used for analyses in two computational experiments involving a combined dataset (Panel (A)) and cross-day comparison (Panel (B)). Each node represents class (drug-trial) used for the AI training and testing procedure. Embedded line values represent AI prediction accuracy obtained from experimental testing runs following CNN training. |