FIGURE SUMMARY
Title

Knocking-down of the Prokineticin receptor 2 affects reveals its complex role in the regulation of the hypothalamus-pituitary-gonadal axis in the zebrafish model

Authors
Bassi, I., Luzzani, F., Marelli, F., Vezzoli, V., Cotellessa, L., Prober, D.A., Persani, L., Gothilf, Y., Bonomi, M.
Source
Full text @ Sci. Rep.
Fig. 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage Range: Shield to Day 4
Fig. 2

Whole-mount in situ hybridization with prokr1a probe (A–F) did not display any signal in the head of zebrafsh embryos. In contrast, prokr1b (G–L) is expressed in cells near the olfactory region at 36 hpf (G,H), 48 hpf (I,J) and 72 hpf (K,L). Tat is similar to gnrh3 expression at these times (M–R). Panels A,C,E,G,I,K,M,O and Q show lateral views. Panels B,D,F,H,J,L,N,P and R show dorsal views of zebrafsh embryos. Scale bar=50µm. Image taken using Leica Application Suite sofware

EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage Range: Prim-25 to Protruding-mouth
Fig. 3

Injection of ctrl-MO (B) or prokr1a-MO (C) does not afect GnRH3 neuron fbers, as they look comparable to uninjected WT (A) embryos. In contrast, knockdown of prokr1b (D) causes alteration in axons migration of the rostral part (dotted square in Fig A) and at the level of the anterior commissure (AC) of the embryos. OB=olfactory bulbs, OC=optic chiasm, AC=anterior commissure. Scale bar=50 µm.

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 5

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage: Adult
PHENOTYPE:
Fish:
Observed In:
Stage: Adult
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.
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