Gene
fshb
- ID
- ZDB-GENE-040806-1
- Name
- follicle stimulating hormone subunit beta
- Symbol
- fshb Nomenclature History
- Previous Names
-
- FSHB
- FSH Beta
- Gth I
- gthI
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables hormone activity. Acts upstream of or within ovarian follicle development; sex determination; and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; endocrine system; female organism; kidney; and male organism. Human ortholog(s) of this gene implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Orthologous to human FSHB (follicle stimulating hormone subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 48 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fshb | (3) | |
| MO1-fshb | N/A | Chen et al., 2012 |
| TALEN1-fshb | (5) | |
| TALEN2-fshb | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 24 without anosmia | Alliance | Hypogonadotropic hypogonadism 24 without anosmia | 229070 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Glycoprotein hormone subunit beta | Gonadotropin, beta subunit | Gonadotropin, beta subunit, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q6TCF7 | InterPro | 130 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-314G15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205624 (1) | 1038 nt | ||
| Genomic | GenBank:BX511109 (1) | 124061 nt | ||
| Polypeptide | UniProtKB:Q6TCF7 (1) | 130 aa |
- Hollander-Cohen, L., Cohen, O., Shulman, M., Aiznkot, T., Fontanaud, P., Revah, O., Mollard, P., Golan, M., Levavi-Sivan, B. (2024) The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion. eLIFE. 13:
- Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Roisman-Geller, N., Pisanty, O., Weinberger, A., Gajbhiye, D.S., Golan, M., Gothilf, Y. (2024) Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish. International Journal of Molecular Sciences. 25(13):
- Tanaka, S., Yu, Y., Levavi-Sivan, B., Zmora, N., Zohar, Y. (2024) Gonadotropin releasing hormone - gonadotropes interactions revealed by pituitary single-cell transcriptomics in zebrafish. Endocrinology. 165(12):
- Wang, M., Luo, J., Dai, L., Feng, M., Cao, X., Zhang, J., Wan, Y., Yang, X., Wang, Y. (2024) Foxp2 deficiency impairs reproduction by modulating the hypothalamic-pituitary-gonadal axis in zebrafish. Biology of reproduction. 110(5):908-923
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Wei, Z., Bagivalu Lakshminarasimha, A., Cone, R., Michel, M. (2023) Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis. General and comparative endocrinology. 336:114243
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
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