Gene

fshb

ID
ZDB-GENE-040806-1
Name
follicle stimulating hormone subunit beta
Symbol
fshb Nomenclature History
Previous Names
  • FSHB
  • FSH Beta
  • Gth I
  • gthI
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables hormone activity. Acts upstream of or within ovarian follicle development; sex determination; and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; endocrine system; female organism; kidney; and male organism. Human ortholog(s) of this gene implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Orthologous to human FSHB (follicle stimulating hormone subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
36 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fshb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 24 without anosmia Alliance Hypogonadotropic hypogonadism 24 without anosmia 229070
Associated With fshb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018245 Gonadotropin, beta subunit, conserved site
Domain IPR006208 Glycoprotein hormone subunit beta
Family IPR001545 Gonadotropin, beta subunit
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Glycoprotein hormone subunit beta Gonadotropin, beta subunit Gonadotropin, beta subunit, conserved site
UniProtKB:Q6QMG0 76
UniProtKB:Q6TCF7 130
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fshb Rabbit
  • WB
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations