Antiangiogenic effects of oridonin in the zebrafish embryos. The average diameters of three blood vessels from the end of the tail were measured and calculated. a control group; b 200 ?g/ml oridonin group; c Diameter length comparison. The asterisks indicate statistically significant differences from the control group (*P < 0.05)

Antiangiogenic effects of oridonin on the larvae. The average lengths of the regenerated tissues were measured and calculated. a control group; b 80 ?g/ml oridonin group; c Length comparison. The asterisks indicate statistically significant differences from the control group (*P < 0.05, **P < 0.01)

Antiangiogenic effect of oridonin in adult zebrafish. The average lengths of the regenerated tissues were measured and calculated. a control group (regular light); b 150 ?g/ml oridonin group (regular light); c control group (fluorescent light); d 150 ?g/ml oridonin group (fluorescent light); e Length comparison. The asterisks indicate statistically significant differences from the control group (*P < 0.05, **P < 0.01)

Tumour metastasis in xenograft zebrafish after 7 d exposure to EM, Avastin, and oridonin. a blank control group (EM); b positive control group (Avastin); c the group (oridonin); d Metastasis area comparison. The asterisks indicate statistically significant differences from the control group (**P < 0.01)