abacavir

Term ID

CHEBI:421707

Synonyms

• Abacavir
• ABC
• {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
• {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol

Definition

A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.

References

• beilstein:7493116
• cas:136470-78-5
• drugbank:DB01048
• drugcentral:34
• kegg.compound:C07624
• kegg.drug:D07057
• pubmed:11678376
• pubmed:11806176
• pubmed:12781181
• pubmed:15887959
• pubmed:16458506
• pubmed:16539393
• pubmed:16759112
• pubmed:17172311
• pubmed:17870541
• pubmed:18029175
• pubmed:18549801
• pubmed:24751900
• pubmed:25017682
• pubmed:25674793
• pubmed:26024233
• reaxys:7493116
• wikipedia.en:Abacavir

Ontology

ChEBI  ( EBI )