6-de(cyclopropylamino)-6-(isopropylamino)abacavir

Term ID

CHEBI:149439

Synonyms

• (1S,4R)-4-[2-amino-6-[(1-methylethyl)amino]-9H-purin-9-yl]-2-cyclopentene-1-methanol
• [(1S,4R)-4-{2-amino-6-[(propan-2-yl)amino]-9H-purin-9-yl}cyclopent-2-en-1-yl]methanol
• {(1S,4R)-4-[2-amino-6-(isopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol

Definition

A 2,6-diaminopurine that is an analogue of abacavir in which the cyclopropylamino group at position 6 of the purine moiety is replaced by a 3-isopropoxyazetidin-1-yl group. Unlike several other synthesised abacavir analogues, it is completely deficient in T-cell reactivity with abacavir-responsive clones.

References

• PMID:26372480
• PMID:31549414

Ontology

ChEBI  ( EBI )