Gene
park7
- ID
- ZDB-GENE-041010-5
- Name
- parkinson protein 7
- Symbol
- park7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have several functions, including peptidase activity; protein deglycase activity; and protein homodimerization activity. Involved in response to oxidative stress. Predicted to localize to cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; cerebral infarction; and middle cerebral artery infarction. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Orthologous to human PARK7 (Parkinsonism associated deglycase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103725 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Parkinson's disease 7 | Alliance | Parkinson disease 7, autosomal recessive early-onset | 606324 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Parkinson's disease | park7ub2000/ub2000 | standard conditions | Edson et al., 2019 |
| retinal degeneration | park7ub2000/ub2000 | standard conditions | Gharbi et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Class I glutamine amidotransferase-like | DJ-1/PfpI | Protein/nucleic acid deglycase | Protein/nucleic acid deglycase DJ-1 |
|---|---|---|---|---|---|
|
UniProtKB:Q5XJ36
|
189 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available