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ZIRC
ZFIN ID: ZDB-GENE-041010-5
Gene Name: parkinson protein 7
Gene Symbol: park7    Nomenclature History

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Previous Names: DJ-1 (1), zDJ-1 (1), zgc:103725

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have several functions, including peptidase activity; protein deglycase activity; and protein homodimerization activity. Involved in response to oxidative stress. Predicted to localize to the cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; cerebral infarction; and middle cerebral artery infarction. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Orthologous to human PARK7 (Parkinsonism associated deglycase).
Genome Resources: Alliance (1),  Gene:449674 (1),  Ensembl(GRCz11):ENSDARG00000116835 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-park7 N/A 1
MO2-park7 N/A 1
MO3-park7 N/A 1
MO4-park7 N/A 1
MO5-park7 N/A 1
PHENOTYPE
Data: Fig. 3 from Baulac et al., 2009
Observed in:
DISEASE ASSOCIATED WITH park7 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 7 Alliance Parkinson disease 7, autosomal recessive early-onset 606324
DISEASE ASSOCIATED WITH park7 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to oxidative stress (more)
Cellular Component mitochondrion (more)
Molecular Function mRNA binding (more)
GO Terms (all 34)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002818 (1)
  • InterPro:IPR006287 (1)
  • InterPro:IPR029062 (1)
  • Pfam:PF01965 (1)
  • EC:3.5.1.124 (1)
  • Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-park7 monoclonal IgM Mouse WB Abcam plc
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM park7
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(gfap:EGFP-2A-FLAG-park7) gfap 2AEGFPFLAGpark7 Danio rerio 1 1
    MARKER RELATIONSHIPS
    park7 Contained in: [BAC] DKEYP-123H11 (1)
    park7 Encodes: [cDNA] MGC:103725 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001005938 (1) 959 bp
    Genomic GenBank:BX571706 (1) 196333 bp
    Select Tool
    Polypeptide UniProtKB:Q5XJ36 (1) 189 aa
    Sequence Clusters UniGene:85181 (1)
    Sequence Information (all 12)
    ORTHOLOGY for park7 ( Chr: 11 )
    CITATIONS (32)