Gene

hpda

ID

ZDB-GENE-040426-986

Name

4-hydroxyphenylpyruvate dioxygenase a

Symbol

hpda Nomenclature History

Previous Names

fb58f02
wu:fb58f02
zgc:56326

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Is expressed in liver. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56326 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hpda Human Ortholog

No data available

Associated With hpda Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018146	Glyoxalase I, conserved site
Domain	IPR004360	Glyoxalase/fosfomycin resistance/dioxygenase domain
Domain	IPR037523	Vicinal oxygen chelate (VOC) domain
Domain	IPR041735	4-hydroxyphenylpyruvate dioxygenase, C-terminal
Domain	IPR041736	4-hydroxyphenylpyruvate dioxygenase, N-terminal
Family	IPR005956	4-hydroxyphenylpyruvate dioxygenase
Homologous_superfamily	IPR029068	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase