Gene
crim1
- ID
- ZDB-GENE-040312-2
- Name
- cysteine rich transmembrane BMP regulator 1 (chordin-like)
- Symbol
- crim1 Nomenclature History
- Previous Names
-
- wu:fc29f08
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have insulin-like growth factor binding activity and serine-type endopeptidase inhibitor activity. Involved in blood vessel development; notochord morphogenesis; and somitogenesis. Predicted to localize to extracellular region and integral component of membrane. Used to study cataract and microphthalmia. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; notochord; otic vesicle; and posterior segment eye. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Brastrom et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | WT + MO1-crim1 | standard conditions | Brastrom et al., 2019 |
| microphthalmia | WT + MO1-crim1 | standard conditions | Brastrom et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR004094 | Antistasin-like domain |
| Domain | IPR045813 | Cysteine-rich motor neuron 1 protein, C-terminal |
| Family | IPR052624 | Cysteine-rich motor neuron 1 |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011061 | Hirudin/antistatin |
Domain Details Per Protein
| Protein | Length | Antistasin-like domain | Cysteine-rich motor neuron 1 | Cysteine-rich motor neuron 1 protein, C-terminal | Growth factor receptor cysteine-rich domain superfamily | Hirudin/antistatin | Insulin-like growth factor-binding protein, IGFBP | VWFC domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T3Q2
|
1027 |
Interactions and Pathways
No data available
Plasmids
No data available