Gene

vps36

ID

ZDB-GENE-030131-7753

Name

vacuolar protein sorting 36 homolog

Symbol

vps36 Nomenclature History

Previous Names

fj33d07
wu:fj33d07
zgc:55965

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable ubiquitin binding activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within endosome transport via multivesicular body sorting pathway and protein transport. Predicted to be located in endosome. Predicted to be part of ESCRT II complex. Predicted to be active in late endosome membrane. Orthologous to human VPS36 (vacuolar protein sorting 36 homolog).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu191 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Gulluni et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps36 Human Ortholog

No data available

Associated With vps36 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021648	Vacuolar protein sorting protein 36, GLUE domain
Family	IPR037855	Vacuolar protein sorting protein 36
Family	IPR040608	Snf8/Vps36 family
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	PH-like domain superfamily	Snf8/Vps36 family	Vacuolar protein sorting protein 36	Vacuolar protein sorting protein 36, GLUE domain	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:Q7ZVK4 InterPro	382

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vps36-201 (1) Ensembl	Ensembl	1,904 nt	Select Tool ZFIN BLAST
mRNA	vps36-202 (1) Ensembl	Ensembl	610 nt	Select Tool ZFIN BLAST
mRNA	vps36-203 (1) Ensembl	Ensembl	658 nt	Select Tool ZFIN BLAST
mRNA	vps36-206 (1) Ensembl	Ensembl	4,791 nt	Select Tool ZFIN BLAST
ncRNA	vps36-002 (1) Ensembl	Ensembl	908 nt	Select Tool ZFIN BLAST
ncRNA	vps36-003 (1) Ensembl	Ensembl	478 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-VPS36	polyclonal	vps36		Rabbit	IHC WB	Sigma-Aldrich Abcam plc	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations