Gene

siah1

ID

ZDB-GENE-010319-31

Name

siah E3 ubiquitin protein ligase 1

Symbol

siah1 Nomenclature History

Previous Names

id:ibd2635
zgc:56026

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in neuron apoptotic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to localize to cytosol and nucleus. Is expressed in germ ring; myotome; and nervous system. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56026 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With siah1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Buratti-Harel syndrome	619314

Associated With siah1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR013010	Zinc finger, SIAH-type
Domain	IPR018121	Seven-in-absentia protein, TRAF-like domain
Domain	IPR049548	E3 ubiquitin-protein ligase Sina-like, RING finger
Family	IPR004162	E3 ubiquitin-protein ligase SINA-like, animal
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type