Gene
siah1
- ID
- ZDB-GENE-010319-31
- Name
- siah E3 ubiquitin protein ligase 1
- Symbol
- siah1 Nomenclature History
- Previous Names
-
- id:ibd2635
- zgc:56026
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in neuron apoptotic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in germ ring; myotome; nervous system; and optic fissure. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56026 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Buratti-Harel syndrome | 619314 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR013010 | Zinc finger, SIAH-type |
| Domain | IPR018121 | Seven-in-absentia protein, TRAF-like domain |
| Domain | IPR049548 | E3 ubiquitin-protein ligase Sina-like, RING finger |
| Family | IPR004162 | E3 ubiquitin-protein ligase SINA-like, animal |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase SINA-like, animal | E3 ubiquitin-protein ligase Sina-like, RING finger | Seven-in-absentia protein, TRAF-like domain | TRAF-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, SIAH-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0H2UKD5 | InterPro | 286 | |||||||
| UniProtKB:Q7ZVG6 | InterPro | 282 | |||||||
| UniProtKB:A0A0R4IPD0 | InterPro | 334 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-siah1 | polyclonal | IgG | Rabbit |
|
Boster Biological
|
2 |
Plasmids
No data available