Gene
siah1
- ID
- ZDB-GENE-010319-31
- Name
- siah E3 ubiquitin protein ligase 1
- Symbol
- siah1 Nomenclature History
- Previous Names
-
- id:ibd2635
- zgc:56026
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in neuron apoptotic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in germ ring; myotome; nervous system; and optic fissure. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56026 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013211Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020302Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa25061 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Buratti-Harel syndrome | 619314 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR013010 | Zinc finger, SIAH-type |
| Domain | IPR018121 | Seven-in-absentia protein, TRAF-like domain |
| Domain | IPR049548 | E3 ubiquitin-protein ligase Sina-like, RING finger |
| Family | IPR004162 | E3 ubiquitin-protein ligase SINA-like, animal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase SINA-like, animal | E3 ubiquitin-protein ligase Sina-like, RING finger | Seven-in-absentia protein, TRAF-like domain | TRAF-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, SIAH-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0H2UKD5 | InterPro | 286 | |||||||
| UniProtKB:Q7ZVG6 | InterPro | 282 | |||||||
| UniProtKB:A0A0R4IPD0 | InterPro | 334 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-siah1 | polyclonal | IgG | Rabbit |
|
Boster Biological
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:dnsiah1) |
|
| 1 | Piedade et al., 2020 | |
| Tg(hsp70l:siah1) |
|
| 1 | Piedade et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-215N5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-27A9 | ZFIN Curated Data | |
| Encodes | EST | ibd2635 | ||
| Encodes | cDNA | MGC:56026 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199521 (1) | 2419 nt | ||
| Genomic | GenBank:BX470163 | 241301 nt | ||
| Polypeptide | UniProtKB:A0A0R4IPD0 (1) | 334 aa |
- Piedade, W.P., Titialii-Torres, K., Morris, A.C., Famulski, J.K. (2020) Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish. Frontiers in cell and developmental biology. 8:594290
- Pereira Piedade, W., Veith, S., Famulski, J.K. (2019) Ubiquitin-mediated proteasome degradation regulates optic fissure fusion. Biology Open. 8(6):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Kang, N., Won, M., Rhee, M., Ro, H. (2014) Siah Ubiquitin Ligases Modulate Nodal Signaling during Zebrafish Embryonic Development. Molecules and cells. 37(5):389-98
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Quiniou, S.M., Wilson, M., and Boudinot, P. (2011) Processing of fish Ig heavy chain transcripts: Diverse splicing patterns and unusual nonsense mediated decay. Developmental and comparative immunology. 35(9):949-58
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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