ZFIN

ZFIN ID: ZDB-TGCONSTRCT-130522-2

ZFIN ID: ZDB-TGCONSTRCT-130522-2

CITATIONS (53 total)

Transgenic Construct Name:	Tg(LCR:EGFP)
Transgenic Construct Symbol:	Tg(LCR:EGFP)

Chen, M., Zhang, Y., Jiang, K., Wang, W., Feng, H., Zhen, R., Moo, C., Zhang, Z., Shi, J., Chen, C. (2022) Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts. Blood. 140(10):1145-1155

Sun, F., Zhao, Z., Willoughby, M.M., Shen, S., Zhou, Y., Shao, Y., Kang, J., Chen, Y., Chen, M., Yuan, X., Hamza, I., Reddi, A.R., Chen, C. (2022) HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Nature. 610(7933):768-774

Wang, Y., Wu, H., Sheng, H., Wang, Y., Li, X., Wang, Y., Zhao, L. (2022) Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 155:113744

Wattrus, S.J., Smith, M.L., Rodrigues, C.P., Hagedorn, E.J., Kim, J.W., Budnik, B., Zon, L.I. (2022) Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science (New York, N.Y.). 377:1413-1419

Zhao, S., Zhang, A., Zhu, H., Wen, Z. (2022) The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development (Cambridge, England). 149(19)

Bell, L.M., Holm, A., Matysiak, U., Driever, W., Rößler, J., Schanze, D., Wieland, I., Niemeyer, C.M., Zenker, M., Kapp, F.G. (2021) Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos. Human molecular genetics. 31(1):10-17

Belmonte, R.L., Engbretson, I.L., Kim, J.H., Cajias, I., Ahn, E.E., Stachura, D.L. (2021) son is necessary for proper vertebrate blood development. PLoS One. 16:e0247489

Cacialli, P., Mahony, C.B., Petzold, T., Bordignon, P., Rougemont, A.L., Bertrand, J.Y. (2021) A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress. Nature communications. 12:4484

Campbell, C.A., Fursova, O., Cheng, X., Snella, E., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., Traver, D., Espín-Palazón, R. (2021) A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood advances. 5:796-811

Lee, L., Perez Oliva, A.B., Martinez-Balsalobre, E., Churikov, D., Peter, J., Rahmouni, D., Audoly, G., Azzoni, V., Audebert, S., Camoin, L., Mulero, V., Cayuela, M.L., Kulathu, Y., Geli, V., Lachaud, C. (2021) UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Science advances. 7:eabc7371

Li, J., Liu, H., Yang, Z., Yu, Q., Zhao, L., Wang, Y. (2021) Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish. Frontiers in pharmacology. 11:622787

Mahony, C.B., Cacialli, P., Pasche, C., Monteiro, R., Savvides, S.N., Bertrand, J.Y. (2021) Hapln1b, a central organizer of the extracellular matrix, modulates kit signalling to control developmental haematopoiesis. Blood advances. 5(23):4935-4948

Rondelli, C.M., Perfetto, M., Danoff, A., Bergonia, H., Gillis, S., O'Neill, L., Jackson, L., Nicolas, G., Puy, H., West, R., Phillips, J.D., Yien, Y.Y. (2021) The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover. The Journal of biological chemistry. 297:100972

Yang, W., Wang, W., Jing, L., Chen, S.L. (2021) Label-free photoacoustic microscopy: a potential tool for the live imaging of blood disorders in zebrafish. Biomedical Optics Express. 12:3643-3657

Crispin, A., Guo, C., Chen, C., Campagna, D.R., Schmidt, P.J., Lichtenstein, D.A., Cao, C., Sendamarai, A.K., Hildick-Smith, G.J., Huston, N.C., Boudreaux, J., Bottomley, S.S., Heeney, M.M., Paw, B.H., Fleming, M.D., Ducamp, S. (2020) Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. The Journal of Clinical Investigation. 130(10):5245-5256

Oltova, J., Svoboda, O., Machonova, O., Svatonova, P., Traver, D., Kolar, M., Bartunek, P. (2020) Zebrafish Kit ligands cooperate with erythropoietin to promote erythroid cell expansion. Blood advances. 4:5915-5924

Xia, Z., Bi, X., Lian, J., Dai, W., He, X., Zhao, L., Min, J., Wang, F. (2020) Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish. Open Biology. 10:200281

Chen, C., Huang, H., Yan, R., Lin, S., Qin, W. (2019) Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia. G3 (Bethesda). 9(12):4149-4157

Kinney, M.A., Vo, L.T., Frame, J.M., Barragan, J., Conway, A.J., Li, S., Wong, K.K., Collins, J.J., Cahan, P., North, T.E., Lauffenburger, D.A., Daley, G.Q. (2019) A systems biology pipeline identifies regulatory networks for stem cell engineering. Nature Biotechnology. 37:810-818

Souders, C.L., Xavier, P., Perez-Rodriquez, V., Ector, N., Zhang, J.L., Martyniuk, C.J. (2019) Sub-lethal effects of the triazole fungicide propiconazole on zebrafish (Danio rerio) development, oxidative respiration, and larval locomotor activity. Neurotoxicology and teratology. 74:106809

Tyrkalska, S.D., Pérez-Oliva, A.B., Rodríguez-Ruiz, L., Martínez-Morcillo, F.J., Alcaraz-Pérez, F., Martínez-Navarro, F.J., Lachaud, C., Ahmed, N., Schroeder, T., Pardo-Sánchez, I., Candel, S., López-Muñoz, A., Choudhuri, A., Rossmann, M.P., Zon, L.I., Cayuela, M.L., García-Moreno, D., Mulero, V. (2019) Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 51(1):50-63.e5

Huang, M., Jiao, J., Wang, J., Xia, Z., Zhang, Y. (2018) Characterization of acrylamide-induced oxidative stress and cardiovascular toxicity in zebrafish embryos. Journal of hazardous materials. 347:451-460

Peters, M.J., Parker, S.K., Grim, J., Allard, C.A.H., Levin, J., Detrich, H.W. (2018) Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish.. Biology Open. 7(8):

Yien, Y.Y., Shi, J., Chen, C., Cheung, J.T., Grillo, A.S., Shrestha, R., Li, L., Zhang, X., Kafina, M.D., Kingsley, P.D., King, M.J., Ablain, J., Li, H., Zon, L., Palis, J., Burke, M.D., Bauer, D.E., Orkin, S.H., Koehler, C.M., Phillips, J.D., Kaplan, J., Ward, D.M., Lodish, H.F., Paw, B.H. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of biological chemistry. 293(51):19797-19811

Zhang, J., Chambers, I., Yun, S., Phillips, J., Krause, M., Hamza, I. (2018) Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney. PLoS Genetics. 14:e1007665

Ziyad, S., Riordan, J.D., Cavanaugh, A.M., Su, T., Hernandez, G.E., Hilfenhaus, G., Morselli, M., Huynh, K., Wang, K., Chen, J.N., Dupuy, A.J., Iruela-Arispe, M.L. (2018) A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell Reports. 22:1211-1224

Chung, J., Wittig, J.G., Ghamari, A., Maeda, M., Dailey, T.A., Bergonia, H., Kafina, M.D., Coughlin, E.E., Minogue, C.E., Hebert, A.S., Li, L., Kaplan, J., Lodish, H.F., Bauer, D.E., Orkin, S.H., Cantor, A.B., Maeda, T., Phillips, J.D., Coon, J.J., Pagliarini, D.J., Dailey, H.A., Paw, B.H. (2017) Erythropoietin signaling regulates heme biosynthesis. eLIFE. 6

Grillo, A.S., SantaMaria, A.M., Kafina, M.D., Cioffi, A.G., Huston, N.C., Han, M., Seo, Y.A., Yien, Y.Y., Nardone, C., Menon, A.V., Fan, J., Svoboda, D.C., Anderson, J.B., Hong, J.D., Nicolau, B.G., Subedi, K., Gewirth, A.A., Wessling-Resnick, M., Kim, J., Paw, B.H., Burke, M.D. (2017) Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (New York, N.Y.). 356:608-616

Huang, M., Jiao, J., Wang, J., Xia, Z., Zhang, Y. (2017) Exposure to acrylamide induces cardiac developmental toxicity in zebrafish during cardiogenesis. Environmental pollution (Barking, Essex : 1987). 234:656-666

Qi, Y., Zhao, X., Liu, H., Wang, Y., Zhao, C., Zhao, T., Zhao, B., Wang, Y. (2017) Identification of a Quality Marker (Q-Marker) of Danhong Injection by the Zebrafish Thrombosis Model. Molecules. 22(9)

Seguin, A., Takahashi-Makise, N., Yien, Y.Y., Huston, N.C., Whitman, J.C., Musso, G., Wallace, J.A., Bradley, T., Bergonia, H., Kafina, M.D., Matsumoto, M., Igarashi, K., Phillips, J.D., Paw, B.H., Kaplan, J., Ward, D.M. (2017) Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes. The Journal of biological chemistry. 292(39):16284-16299

Xia, Z., Wei, J., Li, Y., Wang, J., Li, W., Wang, K., Hong, X., Zhao, L., Chen, C., Min, J., Wang, F. (2017) Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. PLoS Genetics. 13:e1006892

Ear, J., Hsueh, J., Nguyen, M., Zhang, Q., Sung, V., Chopra, R., Sakamoto, K.M., Lin, S. (2016) A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. Journal of genetics and genomics = Yi chuan xue bao. 43(5):307-18

Hagedorn, E.J., Cillis, J.L., Curley, C.R., Patch, T.C., Li, B., Blaser, B.W., Riquelme, R., Zon, L.I., Shah, D.I. (2016) Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. Journal of visualized experiments : JoVE. (112)

Konantz, M., Alghisi, E., Müller, J.S., Lenard, A., Esain, V., Carroll, K.J., Kanz, L., North, T.E., Lengerke, C. (2016) Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. The EMBO journal. 35(21):2315-2331

Lenard, A., Alghisi, E., Daff, H., Donzelli, M., McGinnis, C., Lengerke, C. (2016) Using zebrafish to model erythroid lineage toxicity and regeneration. Haematologica. 101(5):e164-7

Svoboda, O., Stachura, D.L., Machonova, O., Zon, L.I., Traver, D., Bartunek, P. (2016) Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nature Protocols. 11:1007-1020

Ablain, J., Durand, E.M., Yang, S., Zhou, Y., Zon, L.I. (2015) A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish. Developmental Cell. 32(6):756-64

Anderson, H., Patch, T.C., Reddy, P.N., Hagedorn, E.J., Kim, P.G., Soltis, K.A., Chen, M.J., Tamplin, O.J., Frye, M., MacLean, G.A., Hübner, K., Bauer, D.E., Kanki, J.P., Vogin, G., Huston, N.C., Nguyen, M., Fujiwara, Y., Paw, B.H., Vestweber, D., Zon, L.I., Orkin, S.H., Daley, G.Q., Shah, D.I. (2015) Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 126(26):2811-20

Chung, J., Bauer, D.E., Ghamari, A., Nizzi, C.P., Deck, K.M., Kingsley, P.D., Yien, Y.Y., Huston, N.C., Chen, C., Schultz, I.J., Dalton, A.J., Wittig, J.G., Palis, J., Orkin, S.H., Lodish, H.F., Eisenstein, R.S., Cantor, A.B., Paw, B.H. (2015) The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Science signaling. 8:ra34

Ear, J., Huang, H., Wilson, T., Tehrani, Z., Lindgren, A., Sung, V., Laadem, A., Daniel, T.O., Chopra, R., Lin, S. (2015) RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1. Blood. 126(7):880-90

Kardon, J.R., Yien, Y.Y., Huston, N.C., Branco, D.S., Hildick-Smith, G.J., Rhee, K.Y., Paw, B.H., Baker, T.A. (2015) Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. Cell. 161:858-867

Mancias, J.D., Pontano Vaites, L., Nissim, S., Biancur, D.E., Kim, A.J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A.C., Harper, J.W. (2015) Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. eLIFE. 4

Korolnek, T., Zhang, J., Beardsley, S., Scheffer, G.L., Hamza, I. (2014) Control of Metazoan Heme Homeostasis by a Conserved Multidrug Resistance Protein. Cell Metabolism. 19(6):1008-19

Zhang, Y., Ear, J., Yang, Z., Morimoto, K., Zhang, B., Lin, S. (2014) Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death & Disease. 5:e1352

Chen, C., Garcia-Santos, D., Ishikawa, Y., Seguin, A., Li, L., Fegan, K.H., Hildick-Smith, G.J., Shah, D.I., Cooney, J.D., Chen, W., King, M.J., Yien, Y.Y., Schultz, I.J., Anderson, H., Dalton, A.J., Freedman, M.L., Kingsley, P.D., Palis, J., Hattangadi, S.M., Lodish, H.F., Ward, D.M., Kaplan, J., Maeda, T., Ponka, P., and Paw, B.H. (2013) Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation. Cell Metabolism. 17(3):343-352

Cooney, J.D., Hildick-Smith, G.J., Shafizadeh, E., McBride, P.F., Carroll, K.J., Anderson, H., Shaw, G.C., Tamplin, O.J., Branco, D.S., Dalton, A.J., Shah, D.I., Wong, C., Gallagher, P.G., Zon, L.I., North, T.E., and Paw, B.H. (2013) Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology. 373(2):431-441

Hildick-Smith, G.J., Cooney, J.D., Garone, C., Kremer, L.S., Haack, T.B., Thon, J.N., Miyata, N., Lieber, D.S., Calvo, S.E., Akman, H.O., Yien, Y.Y., Huston, N.C., Branco, D.S., Shah, D.I., Freedman, M.L., Koehler, C.M., Italiano, J.E., Merkenschlager, A., Beblo, S., Strom, T.M., Meitinger, T., Freisinger, P., Donati, M.A., Prokisch, H., Mootha, V.K., Dimauro, S., and Paw, B.H. (2013) Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4. American journal of human genetics. 93(5):906-14

Paik, E.J., Mahony, S., White, R.M., Price, E.N., Dibiase, A., Dorjsuren, B., Mosimann, C., Davidson, A.J., Gifford, D., and Zon, L.I. (2013) A cdx4-sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 1(5):425-436

Blanc, L., Ciciotte, S.L., Gwynn, B., Hildick-Smith, G.J., Pierce, E.L., Soltis, K.A., Cooney, J.D., Paw, B.H., and Peters, L.L. (2012) Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 109(30):12099-12104

Ganis, J.J., Hsia, N., Trompouki, E., de Jong, J.L., Dibiase, A., Lambert, J.S., Jia, Z., Sabo, P.J., Weaver, M., Sandstrom, R., Stamatoyannopoulos, J.A., Zhou, Y., and Zon, L.I. (2012) Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Developmental Biology. 366(2):185-194

Additional Citations (2):

Zebrafish Nomenclature Committee (2016) Nomenclature Data Curation (2016). Nomenclature Committee Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.