ZFIN

ZFIN ID: ZDB-GENE-090312-15

ZFIN ID: ZDB-GENE-090312-15

CITATIONS (43 total)

Gene Name:	endoplasmic reticulum to nucleus signaling 2
Gene Symbol:	ern2

Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065

Huttner, I.G., Santiago, C.F., Jacoby, A., Cheng, D., Trivedi, G., Cull, S., Cvetkovska, J., Chand, R., Berger, J., Currie, P.D., Smith, K.A., Fatkin, D. (2023) Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish. Journal of cardiovascular development and disease. 10(10):

Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727

Crouzier, L., Richard, E.M., Diez, C., Denus, M., Peyrel, A., Alzaeem, H., Cubedo, N., Delaunay, T., Maurice, T., Delprat, B. (2022) NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome. Molecular therapy. Methods & clinical development. 27:295-308

Dai, W., Wang, K., Zhen, X., Huang, Z., Liu, L. (2022) Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress. Nutrition & metabolism. 19:23

Di Paola, D., Natale, S., Iaria, C., Cordaro, M., Crupi, R., Siracusa, R., D'Amico, R., Fusco, R., Impellizzeri, D., Cuzzocrea, S., Spanò, N., Gugliandolo, E., Peritore, A.F. (2022) Intestinal Disorder in Zebrafish Larvae (Danio rerio): The Protective Action of N-Palmitoylethanolamide-oxazoline. Life (Basel, Switzerland). 12(1):

Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542

Crouzier, L., Denus, M., Richard, E.M., Tavernier, A., Diez, C., Cubedo, N., Maurice, T., Delprat, B. (2021) Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. International Journal of Molecular Sciences. 22(20):

Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905

Zhang, Y., Jiao, Y., Tao, Y., Li, Z., Yu, H., Han, S., Yang, Y. (2021) Monobutyl phthalate can induce autophagy and metabolic disorders by activating the ire1a-xbp1 pathway in zebrafish liver. Journal of hazardous materials. 412:125243

Sun, L., Ling, Y., Jiang, J., Wang, D., Wang, J., Li, J., Wang, X., Wang, H. (2020) Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq. Chemosphere. 251:126318

Jia, Z.L., Cen, J., Wang, J.B., Zhang, F., Xia, Q., Wang, X., Chen, X.Q., Wang, R.C., Hsiao, C.D., Liu, K.C., Zhang, Y. (2019) Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. 227:541-550

Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Hepatotoxicity induced by Isoniazid/Lipopolysaccharide through ERS-, autophagy- and apoptosis pathway in zebrafish. Antimicrobial Agents and Chemotherapy. 63(5):

Lai, C.Y., Lin, C.Y., Hsu, C.C., Yeh, K.Y., Her, G.M. (2018) Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish. Biochimica et biophysica acta. 1863(8):844-856

Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Liu, W., Zheng, Y. (2018) Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 243:1904-1911

Zhang, Y., Li, S., Li, J., Han, L., He, Q., Wang, R., Wang, X., Liu, K. (2018) Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos. Chemosphere. 197:611-621

Hsu, C.C., Lai, C.Y., Lin, C.Y., Yeh, K.Y., Her, G.M. (2017) MicroRNA-27b Depletion Enhances Endotrophic and Intravascular Lipid Accumulation and Induces Adipocyte Hyperplasia in Zebrafish. International Journal of Molecular Sciences. 19(1)

Tu, H.C., Hsiao, Y.C., Yang, W.Y., Tsai, S.L., Lin, H.K., Liao, C.Y., Lu, J.W., Chou, Y.T., Wang, H.D., Yuh, C.H. (2017) Up-regulation of golgi α-mannosidase IA and down-regulation of golgi α-mannosidase IC activates unfolded protein response during hepatocarcinogenesis. Hepatology communications. 1:230-247

Yeh, K.Y., Lai, C.Y., Lin, C.Y., Hsu, C.C., Lo, C.P., Her, G.M. (2017) ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish. Scientific Reports. 7:16362

Dai, W., Wang, K., Zheng, X., Chen, X., Zhang, W., Zhang, Y., Hou, J., Liu, L. (2015) High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutrition & metabolism. 12:42

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Zheng, X., Dai, W., Chen, X., Wang, K., Zhang, W., Liu, L., Hou, J. (2015) Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. Journal of Biomedical Science. 22:105

Howarth, D.L., Lindtner, C., Vacaru, A.M., Sachidanandam, R., Tsedensodnom, O., Vasilkova, T., Buettner, C., Sadler, K.C. (2014) Activating transcription factor 6 is necessary and sufficient for alcoholic Fatty liver disease in zebrafish. PLoS Genetics. 10:e1004335

Hung, I.C., Cherng, B.W., Hsu, W.M., and Lee, S.J. (2013) Calnexin is required for zebrafish posterior lateral line development. The International journal of developmental biology. 57(5):427-438

Cinaroglu, A., Gao, C., Imrie, D., and Sadler, K.C. (2011) Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. Hepatology (Baltimore, Md.). 54(2):495-508

Additional Citations (18):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Curation of NCBI Gene Data Via Shared Ensembl IDs (Supplemental NCBI Load). Automated Data Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

ZFIN Staff (2013) Curation of NCBI Gene Data Via Shared Vega Gene IDs. Automated Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.