ern2

ID

ZDB-GENE-090312-15

Name

endoplasmic reticulum to nucleus signaling 2

Symbol

ern2 Nomenclature History

Previous Names

si:ch211-14k19.11

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable RNA endonuclease activity; protein serine/threonine kinase activity; and unfolded protein binding activity. Predicted to be involved in IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including ERN2 (endoplasmic reticulum to nucleus signaling 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ern2 Human Ortholog

No data available

Associated With ern2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B496	InterPro	776
UniProtKB:A0A8M9Q0A4	InterPro	777
UniProtKB:A0A8M1QQI8	InterPro	930
UniProtKB:A0A8M9PPK0	InterPro	931
UniProtKB:A0AC58JG39	InterPro	731