Gene
ern2
- ID
- ZDB-GENE-090312-15
- Name
- endoplasmic reticulum to nucleus signaling 2
- Symbol
- ern2 Nomenclature History
- Previous Names
-
- si:ch211-14k19.11
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable endoribonuclease activity; protein serine/threonine kinase activity; and unfolded protein binding activity. Predicted to be involved in IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to act upstream of or within mRNA processing and protein phosphorylation. Predicted to be located in membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. Is expressed in liver. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR010513 | KEN domain |
| Family | IPR045133 | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR038357 | KEN domain superfamily |
| Repeat | IPR018391 | Pyrrolo-quinoline quinone beta-propeller repeat |
Domain Details Per Protein
| Protein | Length | KEN domain | KEN domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Pyrrolo-quinoline quinone beta-propeller repeat | Quinoprotein alcohol dehydrogenase-like superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B496
|
776 | |||||||||
|
UniProtKB:A0A8M9Q0A4
|
777 | |||||||||
|
UniProtKB:A0A8M1QQI8
|
930 | |||||||||
|
UniProtKB:A0A8M9PPK0
|
931 |
Interactions and Pathways
No data available
Plasmids
No data available