ZFIN

ZFIN ID: ZDB-GENE-090311-47

CITATIONS (38 total)

Gene Name:	arachidonate 5-lipoxygenase a
Gene Symbol:	alox5a

Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874

Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):

Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974

Siddiqui, A., Abidin, S.A.Z., Shah, Z.A., Othman, I., Kumari, Y. (2023) Behavioural, genomics and proteomic approach to examine Alzheimer's disease in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 271:109636

Katikaneni, A., Jelcic, M., Gerlach, G.F., Ma, Y., Overholtzer, M., Niethammer, P. (2020) Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nature cell biology. 22(9):1049-1055

Mu, X., Chen, X., Liu, J., Yuan, L., Wang, D., Qian, L., Qian, Y., Shen, G., Huang, Y., Li, X., Li, Y., Lin, X. (2020) A multi-omics approach reveals molecular mechanisms by which phthalates induce cardiac defects in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:113876

Nayak, S., Al Ashhab, A., Zilberg, D., Khozin-Goldberg, I. (2020) Dietary Supplementation with Omega-6 LC-PUFA-Rich Microalgae Regulates Mucosal Immune Response and Promotes Microbial Diversity in the Zebrafish Gut. Biology. 9(6):

Poplimont, H., Georgantzoglou, A., Boulch, M., Walker, H.A., Coombs, C., Papaleonidopoulou, F., Sarris, M. (2020) Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. Current biology : CB. 30(14):2761-2776.e7

Xu, S., Xie, F., Tian, L., Manno, S.H., Manno, F.A.M., Cheng, S.H. (2019) Prolonged neutrophil retention in the wound impairs zebrafish heart regeneration after cryoinjury. Fish & shellfish immunology. 94:447-454

Nayak, S., Khozin-Goldberg, I., Cohen, G., Zilberg, D. (2018) Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection. Frontiers in immunology. 9:1960

Adel, S., Heydeck, D., Kühn, H., Ufer, C. (2016) The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1861(1):1-11

Chai, T., Cui, F., Mu, P., Yang, Y., Xu, N., Yin, Z., Jia, Q., Yang, S., Qiu, J., Wang, C. (2016) Enantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149. Scientific Reports. 6:19478

Chai, T., Cui, F., Mu, X., Yang, Y., Wang, C., Qiu, J. (2016) Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels. PLoS One. 11:e0155263

Chatzopoulou, A., Heijmans, J.P., Burgerhout, E., Oskam, N., Spaink, H.P., Meijer, A.H., Schaaf, M.J. (2016) Glucocorticoid-induced attenuation of the inflammatory response in zebrafish. Endocrinology. 157(7):2772-84

Knight, O.M., Van Der Kraak, G. (2015) The role of eicosanoids in 17α, 20β-dihydroxy-4-pregnen-3-one-induced ovulation and spawning in Danio rerio. General and comparative endocrinology. 213:50-8

Okuno, T., Ishitani, T., Yokomizo, T. (2015) Biochemical Characterization of Three BLT Receptors in Zebrafish. PLoS One. 10:e0117888

Adel, S., Hofheinz, K., Heydeck, D., Kuhn, H., Häfner, A.K. (2014) Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes. Biochimica et biophysica acta. Molecular basis of disease. 1842(10):1460-6

Cannon, J.E., Place, E.S., Eve, A.M., Bradshaw, C.R., Sesay, A., Morrell, N.W., and Smith, J.C. (2013) Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mechanisms of Development. 130(2-3):122-131

Enyedi, B., Kala, S., Nikolich-Zugich, T., and Niethammer, P. (2013) Tissue damage detection by osmotic surveillance. Nature cell biology. 15(9):1123-30

Jansen, C., Hofheinz, K., Vogel, R., Anton, M., Reddanna, P., Kuhn, H., and Walther, M. (2011) Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases, newly cloned zebrafish lipoxygenase1 does not follow the A-vs-G concept. The Journal of biological chemistry. 286(43):37804-12

Additional Citations (18):

ZFIN Staff (2023) Curation of NCBI Gene Data Via Shared Ensembl IDs (Supplemental NCBI Load). Automated Data Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

ZFIN Staff (2013) Curation of NCBI Gene Data Via Shared Vega Gene IDs. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.