Gene

alox5a

ID

ZDB-GENE-090311-47

Name

arachidonate 5-lipoxygenase a

Symbol

alox5a Nomenclature History

Previous Names

ALOX2 (1)
alox5
LOX2 (1)
si:dkey-194n13.2

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process and inflammatory response to wounding. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma	Alliance	{Asthma, diminished response to antileukotriene treatment in}	600807
		{Atherosclerosis, susceptibility to}

Associated With alox5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020833	Lipoxygenase, iron binding site
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Domain	IPR042062	Lipoxygenase, vertebrates, PLAT domain
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily