Gene

alox5a

ID
ZDB-GENE-090311-47
Name
arachidonate 5-lipoxygenase a
Symbol
alox5a Nomenclature History
Previous Names
  • ALOX2 (1)
  • alox5
  • LOX2 (1)
  • si:dkey-194n13.2
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With alox5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, diminished response to antileukotriene treatment in} 600807
{Atherosclerosis, susceptibility to}
Associated With alox5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR020833 Lipoxygenase, iron binding site
Conserved_site IPR020834 Lipoxygenase, conserved site
Domain IPR001024 PLAT/LH2 domain
Domain IPR013819 Lipoxygenase, C-terminal
Domain IPR042062 Lipoxygenase, vertebrates, PLAT domain
Family IPR000907 Lipoxygenase
Family IPR001885 Lipoxygenase, mammalian
Homologous_superfamily IPR036226 Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily IPR036392 PLAT/LH2 domain superfamily
Domain Details Per Protein
Protein Length Lipoxigenase, C-terminal domain superfamily Lipoxygenase Lipoxygenase, conserved site Lipoxygenase, C-terminal Lipoxygenase, iron binding site Lipoxygenase, mammalian Lipoxygenase, vertebrates, PLAT domain PLAT/LH2 domain PLAT/LH2 domain superfamily
UniProtKB:A0A2R8RVT0 674
UniProtKB:B8A697 674
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations