ZFIN

ZFIN ID: ZDB-GENE-080508-1

ZFIN ID: ZDB-GENE-080508-1

CITATIONS (45 total)

Gene Name:	kelch-like ECH-associated protein 1b
Gene Symbol:	keap1b

Bian, L., Nguyen, V.T., Tamaoki, J., Endo, Y., Dong, G., Sato, A., Kobayashi, M. (2023) Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish. Redox Biology. 62:102673102673

Ong, A.J.S., Bladen, C.E., Tigani, T.A., Karamalakis, A.P., Evason, K.J., Brown, K.K., Cox, A.G. (2023) The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2217425120e2217425120

Ravindra, J., Ug, Y., Pandyanda Nanjappa, D., Kalladka, K., Dhakal, R., Chakraborty, A., Chakraborty, G. (2023) Allicin extracted from Allium sativum shows potent anti-cancer and antioxidant properties in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 169:115854115854

Yumimoto, K., Sugiyama, S., Motomura, S., Takahashi, D., Nakayama, K.I. (2023) Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life. Science advances. 9:eadg2379

Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542

Van Hall-Beauvais, A., Poganik, J.R., Huang, K.T., Parvez, S., Zhao, Y., Lin, H.Y., Liu, X., Long, M.J.C., Aye, Y. (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLIFE. 11:

Alifu, Y., Kofuji, S., Sunaga, S., Kusaba, M., Hirayama, J., Nishina, H. (2021) The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish. Biological & pharmaceutical bulletin. 44:1160-1165

Li, E., Wang, Y., Li, Q., Li, L., Wei, L. (2021) Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish. Molecules. 26(17):

Nguyen, V.T., Bian, L., Tamaoki, J., Otsubo, S., Muratani, M., Kawahara, A., Kobayashi, M. (2020) Generation and characterization of keap1a- and keap1b-knockout zebrafish. Redox Biology. 36:101667

Shaw, P., Sen, A., Mondal, P., Dey Bhowmik, A., Rath, J., Chattopadhyay, A. (2020) Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway. Aquatic toxicology (Amsterdam, Netherlands). 228:105622

Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):

Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117

Raghunath, A., Nagarajan, R., Sundarraj, K., Palanisamy, K., Perumal, E. (2019) Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebrafish. Basic & Clinical Pharmacology & Toxicology. 125(3):259-270

Wang, H., Pan, L., Xu, R., Si, L., Zhang, X. (2019) The molecular mechanism of Nrf2-Keap1 signaling pathway in the antioxidant defense response induced by BaP in the scallop Chlamys farreri. Fish & shellfish immunology. 92:489-499

Yamashita, A., Deguchi, J., Honda, Y., Yamada, T., Miyawaki, I., Nishimura, Y., Tanaka, T. (2019) Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish. Journal of Pharmacological and Toxicological Methods. 96:34-45

Sant, K.E., Sinno, P.P., Jacobs, H.M., Timme-Laragy, A.R. (2018) Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 198:92-102

Zheng, J.L., Yuan, S.S., Wu, C.W., Lv, Z.M., Zhu, A.Y. (2017) Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 182:113-119

Lin, C.L., Taggart, A.J., Lim, K.H., Ferraris, L., Cygan, K.J., Creton, R., Huang, Y.T., Fairbrother, W.G. (2016) RNA structure replaces the need for U2AF65 in splicing. Genome research. 26(1):12-23

Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24

Zhao, X., Lorent, K., Wilkins, B., Marchione, D.M., Gillespie, K., Waisbourd-Zinman, O., So, J., Koo, K.A., Shin, D., Porter, J.R., Wells, R.G., Blair, I., Pack, M. (2016) Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology (Baltimore, Md.). 64(3):894-907

Zheng, J.L., Yuan, S.S., Wu, C.W., Lv, Z.M. (2016) Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 180:36-44

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Feiner, N., Murakami, Y., Breithut, L., Mazan, S., Meyer, A., and Kuraku, S. (2013) Saltatory evolution of the ectodermal neural cortex (ENC) gene family at the vertebrate origin. Genome biology and evolution. 5(8):1485-502

Kobayashi, M., Li, L., Iwamoto, N., Nakajima-Takagi, Y., Kaneko, H., Nakayama, Y., Eguchi, M., Wada, Y., Kumagai, Y., and Yamamoto, M. (2009) The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds. Molecular and cellular biology. 29(2):493-502

Li, L., Kobayashi, M., Kaneko, H., Nakajima-Takagi, Y., Nakayama, Y., and Yamamoto, M. (2008) Molecular evolution of Keap1: Two Keap1 molecules with distinctive IVR structures are conserved among fish. The Journal of biological chemistry. 283(6):3248-3255

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (19):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.