Research
Search
Genes / Clones
Expression
Mutants / Tg
Antibodies
Anatomy / GO / Human Disease / Chemical
Publications
Data Mining
Downloads
Data Model
AllianceMine
BioMart
Genomics
BLAST
ZFIN
Ensembl
NCBI
UCSC
Genome Browsers
ZFIN
Ensembl
Vega
GRC
UCSC
NCBI
Resources
Zebrafish Genomics
Other Genome Databases
Resources
General
The Zebrafish Book
Protocol Wiki
Antibody Wiki
Anatomy Atlases
Resources for Students and Educators
Zebrafish Programs
ZF-Health
Husbandry Resources
More...
Resource Centers
Zebrafish International Resource Center (ZIRC)
China Zebrafish Resource Center (CZRC)
European Zebrafish Resource Center (EZRC)
Community
Announcements
News
Meetings
Jobs
Alliance Community Forum
Search
People
Labs
Companies
Societies
International Zebrafish Society (IZFS)
Zebrafish Disease Models Society (ZDMS)
Genetics Society of America (GSA)
Zebrafish Husbandry Association
Support
Nomenclature
Nomenclature Conventions
Line Designations
Wild-Type Lines
Submit a Proposed Gene Name
Submit a Proposed Mutant/Tg Line Name
Publications
Guidelines for Authors
Zebrashare
Citing ZFIN
Using ZFIN
Help & Tips
Glossary
Single Box Search Help
Submit Data
Terms of Use
About Us
About ZFIN
Contact Information
Statistics
Committees
Jobs at ZFIN
Sign In
ZFIN ID:
ZDB-GENE-080104-1
CITATIONS
(75 total)
Gene Name:
leptin receptor
Gene Symbol:
lepr
Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
Bagivalu Lakshminarasimha, A., Page McCaw, P., Möckel, D., Gremse, F., Michel, M. (2021) Leptin system loss of function in the absence of obesity in zebrafish. The Journal of endocrinology. 251(1):41-52
Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
Buerger, A.N., Schmidt, J., Chase, A., Paxaio, C., Patel, T.N., Brumback, B.A., Kane, A.S., Martyniuk, C.J., Bisesi, J.H. (2019) Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate. Environmental pollution (Barking, Essex : 1987). 245:1086-1094
Chen, J., Huang, C., Truong, L., La Du, J., Tilton, S.C., Waters, K.M., Lin, K., Tanguay, R.L., and Dong, Q. (2012) Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology. 302(2-3):129-139
Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474
Craig, T.A., Zhang, Y., McNulty, M.S., Middha, S., Ketha, H., Singh, R.J., Magis, A.T., Funk, C., Price, N.D., Ekker, S.C., and Kumar, R. (2012) Research Resource: Whole Transcriptome RNA Sequencing Detects Multiple 1α,25-Dihydroxyvitamin D3-Sensitive Metabolic Pathways in Developing Zebrafish. Molecular endocrinology (Baltimore, Md.). 26(9):1630-1642
Dalman, M.R., Liu, Q., King, M.D., Bagatto, B., and Londraville, R.L. (2013) Leptin expression affects metabolic rate in zebrafish embryos (D. rerio). Frontiers in Physiology. 4:160
Del Vecchio, G., Murashita, K., Verri, T., Gomes, A.S., Rønnestad, I. (2021) Leptin receptor-deficient (knockout) zebrafish: effects on nutrient acquisition. General and comparative endocrinology. 310:113832
den Broeder, M.J., Moester, M.J.B., Kamstra, J.H., Cenijn, P.H., Davidoiu, V., Kamminga, L.M., Ariese, F., de Boer, J.F., Legler, J. (2017) Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy. International Journal of Molecular Sciences. 18(4)
Faught, E., Vijayan, M.M. (2019) Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth. The Journal of endocrinology. 244(2):261-271
Fei, F., Sun, S., Li, Q., Pei, Z., Wang, L., Zhang, R., Luo, F., Yu, M., Wang, X. (2020) Combinatorial normalization of liver-derived cytokine pathways alleviates hepatic tumor-associated cachexia in zebrafish. Cancer research. 81(4):873-884
Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
Forner-Piquer, I., Maradonna, F., Gioacchini, G., Santangeli, S., Allarà, M., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2017) Dose - specific effects of Di-isononyl phthalate on the endocannabinoid system and on liver of female zebrafish. Endocrinology. 158(10):3462-3476
Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125
Giovannone, D., Paul, S., Schindler, S., Arata, C., Farmer, D.T., Patel, P., Smeeton, J., Crump, J.G. (2019) Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones. eLIFE. 8:
Gupta, A., Christensen, R.G., Rayla, A.L., Lakshmanan, A., Stormo, G.D., and Wolfe, S.A. (2012) An optimized two-finger archive for ZFN-mediated gene targeting. Nature Methods. 9(6):588-590
Hu, Z., Ai, N., Chen, W., Wong, Q.W., Ge, W. (2022) Leptin and Its Signaling Are Not Involved in Zebrafish Puberty Onset. Biology of reproduction. 106(5):928-942
Huang, P., Xiong, S., Kang, J., Mei, J., Gui, J.F. (2018)
Stat5b
Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver.. Frontiers in Physiology. 9:676
Kamstra, K., Rizwan, M.Z., Grattan, D.R., Horsfield, J.A., Tups, A. (2022) Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22207
Kang, J., Hu, J., Karra, R., Dickson, A.L., Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. 532(7598):201-6
Levitas-Djerbi, T., Yelin-Bekerman, L., Lerer-Goldshtein, T., Appelbaum, L. (2015) The Hypothalamic Leptin-Neurotensin-Hypocretin Neuronal Networks in Zebrafish. The Journal of comparative neurology. 523(5):831-48
Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
Liu, Q., Chen, Y., Copeland, D., Ball, H., Duff, R.J., Rockich, B., and Londraville, R.L. (2010) Expression of leptin receptor gene in developing and adult zebrafish. General and comparative endocrinology. 166(2):346-355
Liu, Q., Dalman, M., Chen, Y., Akhter, M., Brahmandam, S., Patel, Y., Lowe, J., Thakkar, M., Gregory, A.V., Phelps, D., Riley, C., and Londraville, R.L. (2012) Knockdown of Leptin A Expression Dramatically Alters Zebrafish Development. General and comparative endocrinology. 178(3):562-572
Lu, J.W., Liao, C.Y., Yang, W.Y., Lin, Y.M., Jin, S.L., Wang, H.D., and Yuh, C.H. (2014) Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. PLoS One. 9(1):e85318
Lu, J.W., Yang, W.Y., Lin, Y.M., Jin, S.L., and Yuh, C.H. (2013) Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta histochemica. 115(7):728-39
Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634
Mania, M., Maruccio, L., Russo, F., Abbate, F., Castaldo, L., D'Angelo, L., de Girolamo, P., Guerrera, M.C., Lucini, C., Madrigrano, M., Levanti, M., Germanà, A. (2017) Expression and distribution of leptin and its receptors in the digestive tract of DIO (diet-induced obese) zebrafish. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 212:37-47
Marín-Juez, R., Jong-Raadsen, S., Yang, S., Spaink, H.P. (2014) Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. The Journal of endocrinology. 222(2):229-41
Michel, M., Page-McCaw, P.S., Chen, W., Cone, R.D. (2016) Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 113(11):3084-9
Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
Prokop, J.W., Duff, R.J., Ball, H.C., Copeland, D.L., and Londraville, R.L. (2012) Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides. 38(2):326-336
Rekha, R.D., Amali, A.A., Her, G.M., Yeh, Y.H., Gong, H.Y., Hu, S.Y., Lin, G.H., and Wu, J.L. (2008) Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio. Toxicology. 243(1-2):11-22
Schultz, L.E., Solin, S.L., Wierson, W.A., Lovan, J.M., Syrkin-Nikolau, J., Lincow, D.E., Severin, A.J., Sakaguchi, D.S., McGrail, M. (2017) Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors. Zebrafish. 14(4):343-356
Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Ramachandran, R. (2019) Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life science alliance. 2(5):
Smeeton, J., Natarajan, N., Anderson, T., Tseng, K.C., Fabian, P., Crump, J.G. (2022) Regeneration of Jaw Joint Cartilage in Adult Zebrafish. Frontiers in cell and developmental biology. 9:777787
Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
Tuttle, M., Dalman, M.R., Liu, Q., Londraville, R.L. (2019) Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (
Danio rerio
). PeerJ. 7:e6848
Van Gennip, J.L.M., Boswell, C.W., Ciruna, B. (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science advances. 4:eaav1781
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
Yang, Q., Yan, C., Wang, X., Gong, Z. (2019) Leptin induces muscle wasting in
kras
-driven hepatocellular carcinoma (HCC) model in zebrafish. Disease models & mechanisms. 12(2):
Zarantoniello, M., Randazzo, B., Gioacchini, G., Truzzi, C., Giorgini, E., Riolo, P., Gioia, G., Bertolucci, C., Osimani, A., Cardinaletti, G., Lucon-Xiccato, T., Milanović, V., Annibaldi, A., Tulli, F., Notarstefano, V., Ruschioni, S., Clementi, F., Olivotto, I. (2020) Zebrafish (Danio rerio) physiological and behavioural responses to insect-based diets: a multidisciplinary approach. Scientific Reports. 10:10648
Zhang, Z., Hou, H., Yu, S., Zhou, C., Zhang, X., Li, N., Zhang, S., Song, K., Lu, Y., Liu, D., Lu, H., Xu, H. (2019) Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia. 68(1):111-127
Zhao, C., Wang, M., Jia, Z., Li, E., Zhao, X., Li, F., Lin, R. (2019) Similar hepatotoxicity response induced by Rhizoma Paridis in zebrafish larvae, cell and rat. Journal of ethnopharmacology. 250:112440
Zhao, X.F., Wan, J., Powell, C., Ramachandran, R., Myers, M.G., Goldman, D. (2014) Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration. Cell Reports. 9(1):272-84
Zhao, Y., Qin, W., Zhang, J.P., Hu, Z.Y., Tong, J.W., Ding, C.B., Peng, Z.G., Zhao, L.X., Song, D.Q., and Jiang, J.D. (2013) HCV IRES-Mediated Core Expression in Zebrafish. PLoS One. 8(3):e56985
Zhou, Y., Guo, W., Lei, L., Sun, Y., Li, R., Guo, Y., Yang, L., Shi, X., Han, J., Zhou, B. (2021) Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition. Environmental pollution (Barking, Essex : 1987). 290:118127
Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
Hu, Z., Ai, N., Chen, W., Wong, Q.W., Ge, W. (2022) Leptin and Its Signaling Are Not Involved in Zebrafish Puberty Onset. Biology of reproduction. 106(5):928-942
Kamstra, K., Rizwan, M.Z., Grattan, D.R., Horsfield, J.A., Tups, A. (2022) Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22207
Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
Smeeton, J., Natarajan, N., Anderson, T., Tseng, K.C., Fabian, P., Crump, J.G. (2022) Regeneration of Jaw Joint Cartilage in Adult Zebrafish. Frontiers in cell and developmental biology. 9:777787
Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
Bagivalu Lakshminarasimha, A., Page McCaw, P., Möckel, D., Gremse, F., Michel, M. (2021) Leptin system loss of function in the absence of obesity in zebrafish. The Journal of endocrinology. 251(1):41-52
Del Vecchio, G., Murashita, K., Verri, T., Gomes, A.S., Rønnestad, I. (2021) Leptin receptor-deficient (knockout) zebrafish: effects on nutrient acquisition. General and comparative endocrinology. 310:113832
Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634
Zhou, Y., Guo, W., Lei, L., Sun, Y., Li, R., Guo, Y., Yang, L., Shi, X., Han, J., Zhou, B. (2021) Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition. Environmental pollution (Barking, Essex : 1987). 290:118127
Fei, F., Sun, S., Li, Q., Pei, Z., Wang, L., Zhang, R., Luo, F., Yu, M., Wang, X. (2020) Combinatorial normalization of liver-derived cytokine pathways alleviates hepatic tumor-associated cachexia in zebrafish. Cancer research. 81(4):873-884
Zarantoniello, M., Randazzo, B., Gioacchini, G., Truzzi, C., Giorgini, E., Riolo, P., Gioia, G., Bertolucci, C., Osimani, A., Cardinaletti, G., Lucon-Xiccato, T., Milanović, V., Annibaldi, A., Tulli, F., Notarstefano, V., Ruschioni, S., Clementi, F., Olivotto, I. (2020) Zebrafish (Danio rerio) physiological and behavioural responses to insect-based diets: a multidisciplinary approach. Scientific Reports. 10:10648
Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
Buerger, A.N., Schmidt, J., Chase, A., Paxaio, C., Patel, T.N., Brumback, B.A., Kane, A.S., Martyniuk, C.J., Bisesi, J.H. (2019) Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate. Environmental pollution (Barking, Essex : 1987). 245:1086-1094
Faught, E., Vijayan, M.M. (2019) Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth. The Journal of endocrinology. 244(2):261-271
Giovannone, D., Paul, S., Schindler, S., Arata, C., Farmer, D.T., Patel, P., Smeeton, J., Crump, J.G. (2019) Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones. eLIFE. 8:
Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Ramachandran, R. (2019) Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life science alliance. 2(5):
Tuttle, M., Dalman, M.R., Liu, Q., Londraville, R.L. (2019) Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (
Danio rerio
). PeerJ. 7:e6848
Yang, Q., Yan, C., Wang, X., Gong, Z. (2019) Leptin induces muscle wasting in
kras
-driven hepatocellular carcinoma (HCC) model in zebrafish. Disease models & mechanisms. 12(2):
Zhang, Z., Hou, H., Yu, S., Zhou, C., Zhang, X., Li, N., Zhang, S., Song, K., Lu, Y., Liu, D., Lu, H., Xu, H. (2019) Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia. 68(1):111-127
Zhao, C., Wang, M., Jia, Z., Li, E., Zhao, X., Li, F., Lin, R. (2019) Similar hepatotoxicity response induced by Rhizoma Paridis in zebrafish larvae, cell and rat. Journal of ethnopharmacology. 250:112440
Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125
Huang, P., Xiong, S., Kang, J., Mei, J., Gui, J.F. (2018)
Stat5b
Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver.. Frontiers in Physiology. 9:676
Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
Van Gennip, J.L.M., Boswell, C.W., Ciruna, B. (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science advances. 4:eaav1781
den Broeder, M.J., Moester, M.J.B., Kamstra, J.H., Cenijn, P.H., Davidoiu, V., Kamminga, L.M., Ariese, F., de Boer, J.F., Legler, J. (2017) Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy. International Journal of Molecular Sciences. 18(4)
Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
Forner-Piquer, I., Maradonna, F., Gioacchini, G., Santangeli, S., Allarà, M., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2017) Dose - specific effects of Di-isononyl phthalate on the endocannabinoid system and on liver of female zebrafish. Endocrinology. 158(10):3462-3476
Mania, M., Maruccio, L., Russo, F., Abbate, F., Castaldo, L., D'Angelo, L., de Girolamo, P., Guerrera, M.C., Lucini, C., Madrigrano, M., Levanti, M., Germanà, A. (2017) Expression and distribution of leptin and its receptors in the digestive tract of DIO (diet-induced obese) zebrafish. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 212:37-47
Schultz, L.E., Solin, S.L., Wierson, W.A., Lovan, J.M., Syrkin-Nikolau, J., Lincow, D.E., Severin, A.J., Sakaguchi, D.S., McGrail, M. (2017) Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors. Zebrafish. 14(4):343-356
Kang, J., Hu, J., Karra, R., Dickson, A.L., Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. 532(7598):201-6
Michel, M., Page-McCaw, P.S., Chen, W., Cone, R.D. (2016) Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 113(11):3084-9
Levitas-Djerbi, T., Yelin-Bekerman, L., Lerer-Goldshtein, T., Appelbaum, L. (2015) The Hypothalamic Leptin-Neurotensin-Hypocretin Neuronal Networks in Zebrafish. The Journal of comparative neurology. 523(5):831-48
Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
Lu, J.W., Liao, C.Y., Yang, W.Y., Lin, Y.M., Jin, S.L., Wang, H.D., and Yuh, C.H. (2014) Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. PLoS One. 9(1):e85318
Marín-Juez, R., Jong-Raadsen, S., Yang, S., Spaink, H.P. (2014) Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. The Journal of endocrinology. 222(2):229-41
Zhao, X.F., Wan, J., Powell, C., Ramachandran, R., Myers, M.G., Goldman, D. (2014) Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration. Cell Reports. 9(1):272-84
Dalman, M.R., Liu, Q., King, M.D., Bagatto, B., and Londraville, R.L. (2013) Leptin expression affects metabolic rate in zebrafish embryos (D. rerio). Frontiers in Physiology. 4:160
Lu, J.W., Yang, W.Y., Lin, Y.M., Jin, S.L., and Yuh, C.H. (2013) Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta histochemica. 115(7):728-39
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
Zhao, Y., Qin, W., Zhang, J.P., Hu, Z.Y., Tong, J.W., Ding, C.B., Peng, Z.G., Zhao, L.X., Song, D.Q., and Jiang, J.D. (2013) HCV IRES-Mediated Core Expression in Zebrafish. PLoS One. 8(3):e56985
Chen, J., Huang, C., Truong, L., La Du, J., Tilton, S.C., Waters, K.M., Lin, K., Tanguay, R.L., and Dong, Q. (2012) Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology. 302(2-3):129-139
Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474
Craig, T.A., Zhang, Y., McNulty, M.S., Middha, S., Ketha, H., Singh, R.J., Magis, A.T., Funk, C., Price, N.D., Ekker, S.C., and Kumar, R. (2012) Research Resource: Whole Transcriptome RNA Sequencing Detects Multiple 1α,25-Dihydroxyvitamin D3-Sensitive Metabolic Pathways in Developing Zebrafish. Molecular endocrinology (Baltimore, Md.). 26(9):1630-1642
Gupta, A., Christensen, R.G., Rayla, A.L., Lakshmanan, A., Stormo, G.D., and Wolfe, S.A. (2012) An optimized two-finger archive for ZFN-mediated gene targeting. Nature Methods. 9(6):588-590
Liu, Q., Dalman, M., Chen, Y., Akhter, M., Brahmandam, S., Patel, Y., Lowe, J., Thakkar, M., Gregory, A.V., Phelps, D., Riley, C., and Londraville, R.L. (2012) Knockdown of Leptin A Expression Dramatically Alters Zebrafish Development. General and comparative endocrinology. 178(3):562-572
Prokop, J.W., Duff, R.J., Ball, H.C., Copeland, D.L., and Londraville, R.L. (2012) Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides. 38(2):326-336
Liu, Q., Chen, Y., Copeland, D., Ball, H., Duff, R.J., Rockich, B., and Londraville, R.L. (2010) Expression of leptin receptor gene in developing and adult zebrafish. General and comparative endocrinology. 166(2):346-355
Rekha, R.D., Amali, A.A., Her, G.M., Yeh, Y.H., Gong, H.Y., Hu, S.Y., Lin, G.H., and Wu, J.L. (2008) Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio. Toxicology. 243(1-2):11-22
Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
Additional Citations (22):
Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.
Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.
Zebrafish Nomenclature Committee (2023) Nomenclature Data Curation (2023). Nomenclature Committee Submission.
Zebrafish Nomenclature Committee (2016) Nomenclature Data Curation (2016). Nomenclature Committee Submission.
Zebrafish Nomenclature Committee (2020) Nomenclature Data Curation (2020). Nomenclature Committee Submission.
Zebrafish Nomenclature Committee (2018) Nomenclature Data Curation (2018). Nomenclature Committee Submission.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.
Zebrafish Nomenclature Committee (2023) Nomenclature Data Curation (2023). Nomenclature Committee Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
Zebrafish Nomenclature Committee (2020) Nomenclature Data Curation (2020). Nomenclature Committee Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
Zebrafish Nomenclature Committee (2018) Nomenclature Data Curation (2018). Nomenclature Committee Submission.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
Zebrafish Nomenclature Committee (2016) Nomenclature Data Curation (2016). Nomenclature Committee Submission.
Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.
Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
Your Input Welcome
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Name:
Institution:
Email address:
Please leave blank:
Subject:
Comments:
Send your comments
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.