ZFIN is now using GRCz12tu for Genomic Data
Gene
lepr
- ID
- ZDB-GENE-080104-1
- Name
- leptin receptor
- Symbol
- lepr Nomenclature History
- Previous Names
-
- obr (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in leptin-mediated signaling pathway and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including oocyte maturation; ovulation; and type B pancreatic cell development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Obesity, morbid, due to leptin receptor deficiency | 614963 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR010457 | Immunoglobulin C2-set-like, ligand-binding |
| Domain | IPR041182 | Leptin receptor, immunoglobulin-like domain |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin C2-set-like, ligand-binding | Immunoglobulin-like fold | Leptin receptor, immunoglobulin-like domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P6L4 | InterPro | 1065 | |||||
| UniProtKB:A0AB32TVW1 | InterPro | 1075 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-lepr | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 | |
| Ab1-lepr | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers