Gene

lepr

ID
ZDB-GENE-080104-1
Name
leptin receptor
Symbol
lepr Nomenclature History
Previous Names
  • obr (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have cytokine binding activity and cytokine receptor activity. Involved in several processes, including response to glucose; sensory organ development; and type B pancreatic cell development. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lepr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Obesity, morbid, due to leptin receptor deficiency 614963
Associated With lepr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003961 Fibronectin type III
Domain IPR010457 Immunoglobulin C2-set-like, ligand-binding
Domain IPR041182 Leptin receptor, immunoglobulin-like domain
Family IPR015752 Leptin receptor
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin C2-set-like, ligand-binding Immunoglobulin-like fold Leptin receptor Leptin receptor, immunoglobulin-like domain
UniProtKB:A0A2R8S073 1085
UniProtKB:F1QMA9 1088
UniProtKB:Q108T6 989
UniProtKB:A8WH80 1091
UniProtKB:A0A2R8QEU4 1079
UniProtKB:F1QUB9 1065
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-lepr polyclonal IgG Goat
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
2
Ab1-lepr polyclonal IgG Goat
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations