ZFIN

ZFIN ID: ZDB-GENE-071218-6

ZFIN ID: ZDB-GENE-071218-6

CITATIONS (41 total)

Gene Name:	leucine-rich repeat kinase 2
Gene Symbol:	lrrk2

Filippini, A., Cannone, E., Mazziotti, V., Carini, G., Mutti, V., Ravelli, C., Gennarelli, M., Schiavone, M., Russo, I. (2024) Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish. Biomolecules. 14(7):

Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576

Cansiz, D., Unal, I., Beler, M., Ustundag, U.V., Ak, E., Emekli-Alturfan, E., Alturfan, A.A. (2023) The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish. Neurotoxicology. 99:14-23

Khalili, A., Safarian, N., van Wijngaarden, E., Zoidl, G.S., Zoidl, G.R., Rezai, P. (2023) Loss of Panx1 function in zebrafish alters motor behavior in a lab-on-chip model of Parkinson's disease. Journal of neuroscience research. 101(12):1814-1825

Moraes, I.B., Paiva, I.M., Moreira-Júnior, R.E., Sartori, B.M., Franco, R.R., Espindola, F.S., Murgas, L.D.S., Brunialti-Godard, A.L. (2023) Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Frontiers in bioscience (Landmark edition). 28:7373

Ünal, İ., Cansız, D., Sürmen, M.G., Sürmen, S., Sezer, Z., Beler, M., Üstündağ, Ü.V., Güzel, E., Alturfan, A.A., Emekli-Alturfan, E. (2022) Identification of Molecular Network of Gut-Brain Axis Associated with Neuroprotective Effects of PPARδ-Ligand Erucic Acid in Rotenone-Induced Parkinson's Disease Model in Zebrafish. The European journal of neuroscience. 57(4):585-606

Li, Z., Cao, P., Meng, H., Li, D., Zhang, Y., Li, Y., Wang, S. (2021) Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease. Journal of hazardous materials. 412:125230

Suzzi, S., Ahrendt, R., Hans, S., Semenova, S.A., Chekuru, A., Wirsching, P., Kroehne, V., Bilican, S., Sayed, S., Winkler, S., Spieß, S., Machate, A., Kaslin, J., Panula, P., Brand, M. (2021) Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain. PLoS Genetics. 17:e1009794

Kesh, S., Kannan, R.R., Balakrishnan, A. (2020) Naringenin alleviates 6-hydroxydopamine induced Parkinsonism in SHSY5Y cells and zebrafish model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108893

Kesh, S., Kannan, R.R., Sivaji, K., Balakrishnan, A. (2020) Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson's disease model. Neuroscience letters. 740:135426

Paiva, I.M., de Carvalho, L.M., Di Chiaccio, I.M., de Lima Assis, I., Sánchez, E.N., Garcia, M.B., Ferreira, F.N.A., Cayuela, M.L., Murgas, L.D.S., Godard, A.L.B. (2020) Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 100:109885

Wint, J.M., Sirotkin, H.I. (2020) Lrrk2 modulation of Wnt signaling during zebrafish development. Journal of neuroscience research. 98(10):1831-1842

Yurtsever, İ., Üstündağ, Ü.V., Ünal, İ., Ateş, P.S., Emekli-Alturfan, E. (2020) Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish. Drug and chemical toxicology. 45(4):1544-1551

Moriya, S., Tan, V.P., Yee, A.K., Parhar, I.S. (2019) pink1, atp13a2 and uchl1 Expressions Are Affected by Inflammation in the Brain. Neuroscience letters. 708:134330

Ünal, İ., Çalışkan-Ak, E., Üstündağ, Ü.V., Ateş, P.S., Alturfan, A.A., Altinoz, M.A., Elmaci, I., Emekli-Alturfan, E. (2019) Neuroprotective Effects of Mitoquinone and Oleandrin on Parkinson's Disease Model in Zebrafish. The International journal of neuroscience. 130(6):574-582

Sheng, D., See, K., Hu, X., Yu, D., Wang, Y., Liu, Q., Li, F., Lu, M., Zhao, J., Liu, J. (2018) Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response. Biochemical and Biophysical Research Communications. 497(4):1104-1109

Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F. (2017) Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish. Neurotoxicology. 58:103-109

Babu, N.S., Murthy, C.L., Kakara, S., Sharma, R., Swamy, C.V., Idris, M.M. (2016) MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9):1407-20

Prabhudesai, S., Bensabeur, F.Z., Abdullah, R., Basak, I., Baez, S., Alves, G., Holtzman, N.G., Larsen, J.P., Møller, S.G. (2016) LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Journal of neuroscience research. 94(8):717-35

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Gao, D., Wu, M., Wang, C., Wang, Y., Zuo, Z. (2015) Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 167:200-208

Ren, G., Xin, S., Li, S., Zhong, H., and Lin, S. (2011) Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish. PLoS One. 6(6):e20630

Sheng, D., Qu, D., Kwok, K.H., Ng, S.S., Lim, A.Y., Aw, S.S., Lee, C.W., Sung, W.K., Tan, E.K., Lufkin, T., Jesuthasan, S., Sinnakaruppan, M., and Liu, J. (2010) Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect. PLoS Genetics. 6(4):e1000914

Additional Citations (18):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.