|ZFIN ID: ZDB-PUB-161122-9|
Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish
Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F.
|Source:||Neurotoxicology 58: 103-109 (Journal)|
|Registered Authors:||Liu, Chun-Feng, Liu, Wenwen, Wang, Fen, Wang, Han, Wang, Yali|
|Keywords:||Parkinson’s disease, non-motor symptoms, rotenone, zebrafish|
|PubMed:||27866991 Full text @ Neurotoxicology|
Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F. (2017) Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish. Neurotoxicology. 58:103-109.
ABSTRACTThe pesticide rotenone is widely used to produce Parkinson's disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior. Furthermore, rotenone-treated fish showed less of an olfactory preference for amino acid, indicating olfactory dysfunction. These behavioral symptoms were associated with decreased levels of dopamine in the brains of rotenone-treated fish. Taken together, these results suggest that rotenone-treated zebrafish are a suitable model of PD.
- Genes / Markers (5)