Research
Search
Genes / Clones
Expression
Mutants / Tg
Antibodies
Anatomy / GO / Human Disease / Chemical
Publications
Data Mining
Downloads
Data Model
AllianceMine
BioMart
Genomics
BLAST
ZFIN
Ensembl
NCBI
UCSC
Genome Browsers
ZFIN
Ensembl
Vega
GRC
UCSC
NCBI
Resources
Zebrafish Genomics
Other Genome Databases
Resources
General
The Zebrafish Book
Protocol Wiki
Antibody Wiki
Anatomy Atlases
Resources for Students and Educators
Zebrafish Programs
ZF-Health
Husbandry Resources
More...
Resource Centers
Zebrafish International Resource Center (ZIRC)
China Zebrafish Resource Center (CZRC)
European Zebrafish Resource Center (EZRC)
Community
Announcements
News
Meetings
Jobs
Alliance Community Forum
Search
People
Labs
Companies
Societies
International Zebrafish Society (IZFS)
Zebrafish Disease Models Society (ZDMS)
Genetics Society of America (GSA)
Zebrafish Husbandry Association
Support
Nomenclature
Nomenclature Conventions
Line Designations
Wild-Type Lines
Submit a Proposed Gene Name
Submit a Proposed Mutant/Tg Line Name
Publications
Guidelines for Authors
Zebrashare
Citing ZFIN
Using ZFIN
Help & Tips
Glossary
Single Box Search Help
Submit Data
Terms of Use
About Us
About ZFIN
Contact Information
Statistics
Committees
Jobs at ZFIN
Sign In
ZFIN ID:
ZDB-GENE-070705-53
CITATIONS
(65 total)
Gene Name:
iodothyronine deiodinase 3b
Gene Symbol:
dio3b
Bagci, E., Heijlen, M., Vergauwen, L., Hagenaars, A., Houbrechts, A.M., Esguerra, C.V., Blust, R., Darras, V.M., Knapen, D. (2015) Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 10:e0123285
Baumann, L., Ros, A., Rehberger, K., Neuhauss, S.C., Segner, H. (2016) Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions. Aquatic toxicology (Amsterdam, Netherlands). 172:44-55
Bohnsack, B.L., and Kahana, A. (2013) Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Developmental Biology. 373(2):300-309
Bouzaffour, M., Rampon, C., Ramaugé, M., Courtin, F., and Vriz, S. (2010) Implication of type 3 deiodinase induction in zebrafish fin regeneration. General and comparative endocrinology. 168(1):88-94
Chen, X., Fang, M., Chernick, M., Wang, F., JingfengYang, ., Yu, Y., Zheng, N., Teraoka, H., Nanba, S., Hiraga, T., Hinton, D.E., Dong, W. (2018) The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). General and comparative endocrinology. 271:73-81
Cheng, Y., Ekker, M., Chan, H.M. (2015) Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio). Ecotoxicology and environmental safety. 112C:7-14
Colella, M., Cuomo, D., Nittoli, V., Amoresano, A., Porciello, A., Reale, C., Roberto, L., Russo, F., Russo, N.A., De Felice, M., Mallardo, M., Ambrosino, C. (2023) A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging. International Journal of Molecular Sciences. 24(3):
de Vrieze, E., van de Wiel, S.M., Zethof, J., Flik, G., Klaren, P.H., Arjona, F.J. (2014) Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish. Endocrinology. 155(6):2320-30
Ding, W., Chen, Y., Sultan, Y., Ma, J., Feng, Y., Li, X. (2022) Effect of Acute Exposure to the Ionic Liquid 1-Methyl-3-octylimidazolium Chloride on the Embryonic Development and Larval Thyroid System of Zebrafish. Animals : an open access journal from MDPI. 12(11)
Dong, W., Macaulay, L.J., Kwok, K.W., Hinton, D.E., and Stapleton, H.M. (2013) Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. Aquatic toxicology (Amsterdam, Netherlands). 132-133:190-199
Fu, J., Guo, Y., Wang, M., Yang, L., Han, J., Lee, J.S., Zhou, B. (2020) Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae. Ecotoxicology and environmental safety. 206:111207
Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., and Vriz, S. (2013) Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Scientific Reports. 3:2084
Guo, C., Chen, X., Song, H., Maynard, M.A., Zhou, Y., Lobanov, A.V., Gladyshev, V.N., Ganis, J.J., Wiley, D., Jugo, R.H., Lee, N.Y., Castroneves, L.A., Zon, L.I., Scanlan, T.S., Feldman, H.A., Huang, S.A. (2014) Intrinsic Expression of a Multiexon Type 3 Deiodinase Gene Controls Zebrafish Embryo Size. Endocrinology. 155(10):4069-80
Guo, Z., Zhang, L., Liu, X., Yu, Y., Liu, S., Chen, M., Huang, C., Hu, G. (2019) The enrichment and purification of hexabromocyclododecanes and its effects on thyroid in zebrafish. Ecotoxicology and environmental safety. 185:109690
Haggard, D.E., Noyes, P.D., Waters, K.M., Tanguay, R.L. (2018) Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reproductive toxicology (Elmsford, N.Y.). 77:80-93
Heijlen, M., Houbrechts, A.M., and Darras, V.M. (2013) Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development. General and comparative endocrinology. 188:289-96
Heijlen, M., Houbrechts, A.M., Bagci, E., Van Herck, S.L., Kersseboom, S., Esguerra, C.V., Blust, R., Visser, T.J., Knapen, D., and Darras, V.M. (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 155(4):1547-1559
Houbrechts, A.M., Beckers, A., Vancamp, P., Sergeys, J., Gysemans, C., Mathieu, C., Darras, V.M. (2019) Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish. Endocrinology. 160(11):2759-2772
Houbrechts, A.M., Delarue, J., Gabriëls, I.J., Sourbron, J., Darras, V.M. (2016) Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 157:3668-81
Houbrechts, A.M., Van Houcke, J., Darras, V.M. (2019) Disruption of deiodinase type 2 in zebrafish disturbs male and female reproduction. The Journal of endocrinology.
Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M. (2016) Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Molecular and Cellular Endocrinology. 424:81-93
Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
Lee, S., Eghan, K., Lee, J., Yoo, D., Yoon, S., Kim, W.K. (2020) Zebrafish Embryonic Exposure to BPAP and Its Relatively Weak Thyroid Hormone-Disrupting Effects. Toxics. 8(4):
Li, J., Dong, T., Keerthisinghe, T.P., Chen, H., Li, M., Chu, W., Yang, J., Hu, Z., Snyder, S.A., Dong, W., Fang, M. (2020) Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of hazardous materials. 399:123061
Li, M., Yao, L., Chen, H., Ni, X., Xu, Y., Dong, W., Fang, M., Chen, D., Aowuliji, ., Xu, L., Zhao, B., Deng, J., Kwok, K.W., Yang, J., Dong, W. (2020) Chiral toxicity of muscone to embryonic zebrafish heart. Aquatic toxicology (Amsterdam, Netherlands). 222:105451
Liu, L., Li, Y., Coelhan, M., Chan, H.M., Ma, W., Liu, L. (2016) Relative developmental toxicity of short-chain chlorinated paraffins in Zebrafish (Danio rerio) embryos. Environmental pollution (Barking, Essex : 1987). 219:1122-1130
Marelli, F., Carra, S., Agostini, M., Cotelli, F., Peeters, R., Chatterjee, K., Persani, L. (2016) Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Molecular and Cellular Endocrinology. 424:102-17
Marelli, F., Carra, S., Rurale, G., Cotelli, F., Persani, L. (2017) In vivo functional consequences of human THRA variants expressed in the zebrafish. Thyroid : official journal of the American Thyroid Association. 27(2):279-291
Mariotti, M., Ridge, P.G., Zhang, Y., Lobanov, A.V., Pringle, T.H., Guigo, R., Hatfield, D.L., Gladyshev, V.N. (2012) Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes. PLoS One. 7(3):e33066
Owusu Poku, E., Fonte, M.R., Jensen, T.J., Inman, S.P., Mackin, R.D., Stenkamp, D.L. (2025) Thyroid hormone receptor beta-2 (TRβ2) overexpression modulates photoreceptor phenotype diversity in a ligand-dependent manner. Frontiers in cell and developmental biology. 13:16979301697930
Parsons, A., Lange, A., Hutchinson, T.H., Miyagawa, S., Iguchi, T., Kudoh, T., Tyler, C.R. (2019) Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 209:99-112
Parsons, A.E., Lange, A., Hutchinson, T.H., Miyagawa, S., Iguchi, T., Kudoh, T., Tyler, C.R. (2020) Expression dynamics of genes in the hypothalamic-pituitary-thyroid (HPT) cascade and their responses to 3,3',5-triiodo-l-thyronine (T3) highlights potential vulnerability to thyroid-disrupting chemicals in zebrafish (Danio rerio) embryo-larvae. Aquatic toxicology (Amsterdam, Netherlands). 225:105547
Ren, X., Wang, W., Zhao, X., Ren, B., Chang, L. (2019) Parental exposure to tris(1,3-dichloro-2-propyl) phosphate results in thyroid endocrine disruption and inhibition of growth in zebrafish offspring. Aquatic toxicology (Amsterdam, Netherlands). 209:132-141
Sarasquete, C., Úbeda-Manzanaro, M., Ortiz-Delgado, J.B. (2018) Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 211:57-67
Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
Shah, S.M., Wahba, M., Yu, L., Achari, G., Habibi, H.R. (2019) Health Impact Assessment of Sulfolane on Embryonic Development of Zebrafish (
Danio rerio
). Toxics. 7(3)
Tonyushkina, K., Krug, S., Ortiz-Toro, T., Mascari, T., Karlstrom, R. (2017) Low thyroid hormone levels disrupt thyrotrope development. Endocrinology. 158(9):2774-2782
Tonyushkina, K.N., Shen, M.C., Ortiz-Toro, T., and Karlstrom, R.O. (2014) Embryonic exposure to excess thyroid hormone causes thyrotrope cell death. J. Clin. Invest.. 124(1):321-327
van der Spek, A.H., Jim, K.K., Karaczyn, A., van Beeren, H.C., Ackermans, M.T., Darras, V.M., Vandenbroucke-Grauls, C.M.J.E., Hernandez, A., Brouwer, M.C., Fliers, E., van de Beek, D., Boelen, A. (2017) The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species. Endocrinology. 159(2):826-835
Vatine, G.D., Zada, D., Lerer-Goldshtein, T., Tovin, A., Malkinson, G., Yaniv, K., and Appelbaum, L. (2013) Zebrafish as a model for monocarboxyl transporter 8-deficiency. The Journal of biological chemistry. 288(1):169-180
Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024)
Samd7
represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
Walpita, C.N., Crawford, A.D., and Darras, V.M. (2010) Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio). General and comparative endocrinology. 166(1):134-141
Walter, K.M., Dach, K., Hayakawa, K., Giersiefer, S., Heuer, H., Lein, P.J., Fritsche, E. (2019) Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 14:e0221230
Walter, K.M., Miller, G.W., Chen, X., Yaghoobi, B., Puschner, B., Lein, P.J. (2018) Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and comparative endocrinology. 272:20-32
Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104
Wang, X., Ling, S., Guan, K., Luo, X., Chen, L., Han, J., Zhang, W., Mai, B.X., Zhou, B. (2019) Bioconcentration, biotransformation, and thyroid endocrine disruption of decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, in zebrafish larvae. Environmental science & technology. 53(14):8437-8446
Wei, P., Zhao, F., Zhang, X., Liu, W., Jiang, G., Wang, H., Ru, S. (2018) Transgenerational thyroid endocrine disruption induced by bisphenol S affects the early development of zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 243:800-808
Wu, L., Ru, H., Ni, Z., Zhang, X., Xie, H., Yao, F., Zhang, H., Li, Y., Zhong, L. (2019) Comparative thyroid disruption by o,p'-DDT and p,p'-DDE in zebrafish embryos/larvae. Aquatic toxicology (Amsterdam, Netherlands). 216:105280
Yang, J., Chan, K.M. (2015) Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 159C:138-147
Yang, J., Zhao, H., Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99-induced
cyp1a
mRNA in zebrafish larvae.. Toxicology reports. 4:614-624
Zada, D., Tovin, A., Lerer-Goldshtein, T., Vatine, G.D., Appelbaum, L. (2014) Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation. PLoS Genetics. 10:e1004615
Zhang, D.H., Zhou, E.X., Yang, Z.L. (2017) Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS One. 12:e0176927
Zhou, Z., Yang, J., Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 191:175-188
Owusu Poku, E., Fonte, M.R., Jensen, T.J., Inman, S.P., Mackin, R.D., Stenkamp, D.L. (2025) Thyroid hormone receptor beta-2 (TRβ2) overexpression modulates photoreceptor phenotype diversity in a ligand-dependent manner. Frontiers in cell and developmental biology. 13:16979301697930
Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024)
Samd7
represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
Colella, M., Cuomo, D., Nittoli, V., Amoresano, A., Porciello, A., Reale, C., Roberto, L., Russo, F., Russo, N.A., De Felice, M., Mallardo, M., Ambrosino, C. (2023) A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging. International Journal of Molecular Sciences. 24(3):
Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
Ding, W., Chen, Y., Sultan, Y., Ma, J., Feng, Y., Li, X. (2022) Effect of Acute Exposure to the Ionic Liquid 1-Methyl-3-octylimidazolium Chloride on the Embryonic Development and Larval Thyroid System of Zebrafish. Animals : an open access journal from MDPI. 12(11)
Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104
Fu, J., Guo, Y., Wang, M., Yang, L., Han, J., Lee, J.S., Zhou, B. (2020) Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae. Ecotoxicology and environmental safety. 206:111207
Lee, S., Eghan, K., Lee, J., Yoo, D., Yoon, S., Kim, W.K. (2020) Zebrafish Embryonic Exposure to BPAP and Its Relatively Weak Thyroid Hormone-Disrupting Effects. Toxics. 8(4):
Li, J., Dong, T., Keerthisinghe, T.P., Chen, H., Li, M., Chu, W., Yang, J., Hu, Z., Snyder, S.A., Dong, W., Fang, M. (2020) Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of hazardous materials. 399:123061
Li, M., Yao, L., Chen, H., Ni, X., Xu, Y., Dong, W., Fang, M., Chen, D., Aowuliji, ., Xu, L., Zhao, B., Deng, J., Kwok, K.W., Yang, J., Dong, W. (2020) Chiral toxicity of muscone to embryonic zebrafish heart. Aquatic toxicology (Amsterdam, Netherlands). 222:105451
Parsons, A.E., Lange, A., Hutchinson, T.H., Miyagawa, S., Iguchi, T., Kudoh, T., Tyler, C.R. (2020) Expression dynamics of genes in the hypothalamic-pituitary-thyroid (HPT) cascade and their responses to 3,3',5-triiodo-l-thyronine (T3) highlights potential vulnerability to thyroid-disrupting chemicals in zebrafish (Danio rerio) embryo-larvae. Aquatic toxicology (Amsterdam, Netherlands). 225:105547
Guo, Z., Zhang, L., Liu, X., Yu, Y., Liu, S., Chen, M., Huang, C., Hu, G. (2019) The enrichment and purification of hexabromocyclododecanes and its effects on thyroid in zebrafish. Ecotoxicology and environmental safety. 185:109690
Houbrechts, A.M., Beckers, A., Vancamp, P., Sergeys, J., Gysemans, C., Mathieu, C., Darras, V.M. (2019) Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish. Endocrinology. 160(11):2759-2772
Houbrechts, A.M., Van Houcke, J., Darras, V.M. (2019) Disruption of deiodinase type 2 in zebrafish disturbs male and female reproduction. The Journal of endocrinology.
Parsons, A., Lange, A., Hutchinson, T.H., Miyagawa, S., Iguchi, T., Kudoh, T., Tyler, C.R. (2019) Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 209:99-112
Ren, X., Wang, W., Zhao, X., Ren, B., Chang, L. (2019) Parental exposure to tris(1,3-dichloro-2-propyl) phosphate results in thyroid endocrine disruption and inhibition of growth in zebrafish offspring. Aquatic toxicology (Amsterdam, Netherlands). 209:132-141
Shah, S.M., Wahba, M., Yu, L., Achari, G., Habibi, H.R. (2019) Health Impact Assessment of Sulfolane on Embryonic Development of Zebrafish (
Danio rerio
). Toxics. 7(3)
Walter, K.M., Dach, K., Hayakawa, K., Giersiefer, S., Heuer, H., Lein, P.J., Fritsche, E. (2019) Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 14:e0221230
Wang, X., Ling, S., Guan, K., Luo, X., Chen, L., Han, J., Zhang, W., Mai, B.X., Zhou, B. (2019) Bioconcentration, biotransformation, and thyroid endocrine disruption of decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, in zebrafish larvae. Environmental science & technology. 53(14):8437-8446
Wu, L., Ru, H., Ni, Z., Zhang, X., Xie, H., Yao, F., Zhang, H., Li, Y., Zhong, L. (2019) Comparative thyroid disruption by o,p'-DDT and p,p'-DDE in zebrafish embryos/larvae. Aquatic toxicology (Amsterdam, Netherlands). 216:105280
Chen, X., Fang, M., Chernick, M., Wang, F., JingfengYang, ., Yu, Y., Zheng, N., Teraoka, H., Nanba, S., Hiraga, T., Hinton, D.E., Dong, W. (2018) The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). General and comparative endocrinology. 271:73-81
Haggard, D.E., Noyes, P.D., Waters, K.M., Tanguay, R.L. (2018) Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reproductive toxicology (Elmsford, N.Y.). 77:80-93
Sarasquete, C., Úbeda-Manzanaro, M., Ortiz-Delgado, J.B. (2018) Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 211:57-67
Walter, K.M., Miller, G.W., Chen, X., Yaghoobi, B., Puschner, B., Lein, P.J. (2018) Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and comparative endocrinology. 272:20-32
Wei, P., Zhao, F., Zhang, X., Liu, W., Jiang, G., Wang, H., Ru, S. (2018) Transgenerational thyroid endocrine disruption induced by bisphenol S affects the early development of zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 243:800-808
Marelli, F., Carra, S., Rurale, G., Cotelli, F., Persani, L. (2017) In vivo functional consequences of human THRA variants expressed in the zebrafish. Thyroid : official journal of the American Thyroid Association. 27(2):279-291
Tonyushkina, K., Krug, S., Ortiz-Toro, T., Mascari, T., Karlstrom, R. (2017) Low thyroid hormone levels disrupt thyrotrope development. Endocrinology. 158(9):2774-2782
van der Spek, A.H., Jim, K.K., Karaczyn, A., van Beeren, H.C., Ackermans, M.T., Darras, V.M., Vandenbroucke-Grauls, C.M.J.E., Hernandez, A., Brouwer, M.C., Fliers, E., van de Beek, D., Boelen, A. (2017) The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species. Endocrinology. 159(2):826-835
Yang, J., Zhao, H., Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99-induced
cyp1a
mRNA in zebrafish larvae.. Toxicology reports. 4:614-624
Zhang, D.H., Zhou, E.X., Yang, Z.L. (2017) Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS One. 12:e0176927
Zhou, Z., Yang, J., Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 191:175-188
Baumann, L., Ros, A., Rehberger, K., Neuhauss, S.C., Segner, H. (2016) Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions. Aquatic toxicology (Amsterdam, Netherlands). 172:44-55
Houbrechts, A.M., Delarue, J., Gabriëls, I.J., Sourbron, J., Darras, V.M. (2016) Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 157:3668-81
Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M. (2016) Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Molecular and Cellular Endocrinology. 424:81-93
Liu, L., Li, Y., Coelhan, M., Chan, H.M., Ma, W., Liu, L. (2016) Relative developmental toxicity of short-chain chlorinated paraffins in Zebrafish (Danio rerio) embryos. Environmental pollution (Barking, Essex : 1987). 219:1122-1130
Marelli, F., Carra, S., Agostini, M., Cotelli, F., Peeters, R., Chatterjee, K., Persani, L. (2016) Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Molecular and Cellular Endocrinology. 424:102-17
Bagci, E., Heijlen, M., Vergauwen, L., Hagenaars, A., Houbrechts, A.M., Esguerra, C.V., Blust, R., Darras, V.M., Knapen, D. (2015) Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 10:e0123285
Cheng, Y., Ekker, M., Chan, H.M. (2015) Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio). Ecotoxicology and environmental safety. 112C:7-14
Yang, J., Chan, K.M. (2015) Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 159C:138-147
de Vrieze, E., van de Wiel, S.M., Zethof, J., Flik, G., Klaren, P.H., Arjona, F.J. (2014) Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish. Endocrinology. 155(6):2320-30
Guo, C., Chen, X., Song, H., Maynard, M.A., Zhou, Y., Lobanov, A.V., Gladyshev, V.N., Ganis, J.J., Wiley, D., Jugo, R.H., Lee, N.Y., Castroneves, L.A., Zon, L.I., Scanlan, T.S., Feldman, H.A., Huang, S.A. (2014) Intrinsic Expression of a Multiexon Type 3 Deiodinase Gene Controls Zebrafish Embryo Size. Endocrinology. 155(10):4069-80
Heijlen, M., Houbrechts, A.M., Bagci, E., Van Herck, S.L., Kersseboom, S., Esguerra, C.V., Blust, R., Visser, T.J., Knapen, D., and Darras, V.M. (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 155(4):1547-1559
Tonyushkina, K.N., Shen, M.C., Ortiz-Toro, T., and Karlstrom, R.O. (2014) Embryonic exposure to excess thyroid hormone causes thyrotrope cell death. J. Clin. Invest.. 124(1):321-327
Zada, D., Tovin, A., Lerer-Goldshtein, T., Vatine, G.D., Appelbaum, L. (2014) Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation. PLoS Genetics. 10:e1004615
Bohnsack, B.L., and Kahana, A. (2013) Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Developmental Biology. 373(2):300-309
Dong, W., Macaulay, L.J., Kwok, K.W., Hinton, D.E., and Stapleton, H.M. (2013) Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. Aquatic toxicology (Amsterdam, Netherlands). 132-133:190-199
Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., and Vriz, S. (2013) Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Scientific Reports. 3:2084
Heijlen, M., Houbrechts, A.M., and Darras, V.M. (2013) Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development. General and comparative endocrinology. 188:289-96
Vatine, G.D., Zada, D., Lerer-Goldshtein, T., Tovin, A., Malkinson, G., Yaniv, K., and Appelbaum, L. (2013) Zebrafish as a model for monocarboxyl transporter 8-deficiency. The Journal of biological chemistry. 288(1):169-180
Mariotti, M., Ridge, P.G., Zhang, Y., Lobanov, A.V., Pringle, T.H., Guigo, R., Hatfield, D.L., Gladyshev, V.N. (2012) Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes. PLoS One. 7(3):e33066
Bouzaffour, M., Rampon, C., Ramaugé, M., Courtin, F., and Vriz, S. (2010) Implication of type 3 deiodinase induction in zebrafish fin regeneration. General and comparative endocrinology. 168(1):88-94
Walpita, C.N., Crawford, A.D., and Darras, V.M. (2010) Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio). General and comparative endocrinology. 166(1):134-141
Additional Citations (12):
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
ZFIN Staff (2019) Semi-automated association of ENSDARG and ENSDART identifiers with ZFIN genes and transcripts. Semi-automated Curation.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
ZFIN Staff (2023) Curation of NCBI Gene Data Via Shared Ensembl IDs (Supplemental NCBI Load). Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2023) Curation of NCBI Gene Data Via Shared Ensembl IDs (Supplemental NCBI Load). Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2019) Semi-automated association of ENSDARG and ENSDART identifiers with ZFIN genes and transcripts. Semi-automated Curation.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
Your Input Welcome
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Name:
Institution:
Email address:
Please leave blank:
Subject:
Comments:
Send your comments
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.