ZFIN

ZFIN ID: ZDB-GENE-060503-414

ZFIN ID: ZDB-GENE-060503-414

CITATIONS (50 total)

Gene Name:	scleraxis bHLH transcription factor a
Gene Symbol:	scxa

Kayman Kürekçi, G., Kaur Bajwa, G., Zhang, S., Leclerc, S., de Chantal, E., Belke, D., Andelfinger, G., Deniset, J.F., Marín-Juez, R. (2026) Attenuation of epicardial activation and myofibroblast abundance via the Fbln2-Nupr1b axis stimulates cardiac regeneration in zebrafish. Nature cardiovascular research. :

Méndez-Olivos, E.E., Kocha, K.M., Bloomekatz, J., Liao, S., Huang, P. (2025) Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish. PLoS Biology. 23:e3003365e3003365

Nayak, P.K., Subramanian, A., Schilling, T.F. (2025) Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes. eLIFE. 14:

Xie, L., Ma, R.C., Kocha, K.M., Méndez-Olivos, E.E., Huang, P. (2025) Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish. Development (Cambridge, England). :

Zhang, X., Che, J., Li, Z., Bao, B., Fan, C. (2025) The Mutation of piezo1 Weakens the Intermuscular Bones in Zebrafish and Crucian Carp. International Journal of Molecular Sciences. 26:

Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):

Niu, X., Melendez, D.L., Raj, S., Cai, J., Senadeera, D., Mandelbaum, J., Shestopalov, I.A., Martin, S.D., Zon, L.I., Schlaeger, T.M., Lai, L.P., McMahon, A.P., Craft, A.M., Galloway, J.L. (2024) A conserved transcription factor regulatory program promotes tendon fate. Developmental Cell. 59(23):3106-3123.e12

Anderson, T., Mo, J., Gagarin, E., Sherwood, D., Blumenkrantz, M., Mao, E., Leon, G., Levitz, H., Chen, H.J., Tseng, K.C., Fabian, P., Crump, J.G., Smeeton, J. (2023) Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration. NPJ Regenerative medicine. 8:5151

Chen, H.J., Barske, L., Talbot, J.C., Dinwoodie, O.M., Roberts, R.R., Farmer, D.T., Jimenez, C., Merrill, A.E., Tucker, A.S., Crump, J.G. (2023) Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. Developmental Cell. 58(6):461-473.e7

England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88

Ma, R.C., Kocha, K.M., Méndez-Olivos, E.E., Ruel, T.D., Huang, P. (2023) Origin and diversification of fibroblasts from the sclerotome in zebrafish. Developmental Biology. 498:35-48

Subramanian, A., Kanzaki, L.F., Schilling, T.F. (2023) Mechanical force regulates Sox9 expression at the developing enthesis. Development (Cambridge, England). 150(16):

Sunadome, K., Erickson, A.G., Kah, D., Fabry, B., Adori, C., Kameneva, P., Faure, L., Kanatani, S., Kaucka, M., Dehnisch Ellström, I., Tesarova, M., Zikmund, T., Kaiser, J., Edwards, S., Maki, K., Adachi, T., Yamamoto, T., Fried, K., Adameyko, I. (2023) Directionality of developing skeletal muscles is set by mechanical forces. Nature communications. 14:30603060

Blackwell, D.L., Fraser, S.D., Caluseriu, O., Vivori, C., Tyndall, A.V., Lamont, R.E., Parboosingh, J.S., Innes, A.M., Bernier, F.P., Childs, S.J. (2022) Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3 (Bethesda). 12(5):

Malbouyres, M., Guiraud, A., Lefrançois, C., Salamito, M., Nauroy, P., Bernard, L., Sohm, F., Allard, B., Ruggiero, F. (2022) Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 109:1-18

Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b^-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152

Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471

Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):

Kuriki, M., Sato, F., Arai, H.N., Sogabe, M., Kaneko, M., Kiyonari, H., Kawakami, K., Yoshimoto, Y., Shukunami, C., Sehara-Fujisawa, A. (2020) Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development (Cambridge, England). 147(9):

Niu, X., Subramanian, A., Hwang, T.H., Schilling, T.F., Galloway, J.L. (2020) Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling. Current biology : CB. 30(17):3277-3292.e5

Kague, E., Hughes, S.M., A Lawrence, E., Cross, S., Martin-Silverstone, E., Hammond, C.L., Hinits, Y. (2019) Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(8):9116-9130

Conith, M.R., Hu, Y., Conith, A.J., Maginnis, M.A., Webb, J.F., Albertson, R.C. (2018) Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus. Proceedings of the National Academy of Sciences of the United States of America. 115(27):7063-7068

Ma, R.C., Jacobs, C.T., Sharma, P., Kocha, K.M., Huang, P. (2018) Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish. PLoS Genetics. 14:e1007775

Subramanian, A., Kanzaki, L.F., Galloway, J.L., Schilling, T.F. (2018) Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling. eLIFE. 7:

McGurk, P.D., Swartz, M.E., Chen, J.W., Galloway, J.L., Eberhart, J.K. (2017) In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw. PLoS Genetics. 13:e1007112

Nichols, J.T., Blanco-Sánchez, B., Brooks, E.P., Parthasarathy, R., Dowd, J., Subramanian, A., Nachtrab, G., Poss, K.D., Schilling, T.F., Kimmel, C.B. (2016) Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development (Cambridge, England). 143(23):4430-4440

Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Chen, J.W., Galloway, J.L. (2014) The development of zebrafish tendon and ligament progenitors. Development (Cambridge, England). 141:2035-45

Wang, Y., Chen, K., Yao, Q., Zheng, X., and Yang, Z. (2009) Phylogenetic Analysis of Zebrafish Basic Helix-Loop-Helix Transcription Factors. Journal of molecular evolution. 68(6):629-640

Additional Citations (20):

Zebrafish Nomenclature Committee (2026) Nomenclature Data Curation (2026). Nomenclature Committee Submission.

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

ZFIN Staff (2013) Curation of NCBI Gene Data Via Shared Vega Gene IDs. Automated Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) Temporary Manual Curation. Manually curated data.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.