ZFIN

ZFIN ID: ZDB-GENE-040718-338

CITATIONS (31 total)

Gene Name:	egl-9 family hypoxia-inducible factor 1b
Gene Symbol:	egln1b

Wang, C.F., Cui, X.N., Lv, L.X., Wang, W.H., Jing, Q.Q., Yin, J.N., Cao, X.Z., Wei, M.Y., Lu, L., Shao, C.L. (2025) Discovery of Oral Natural Benzofuranoid p-Terphenyl Derivative CHNQD-03301 as a Potent Hypoxia-Inducible Factor-1α Signaling Inhibitor for Cancer Therapy. Journal of medicinal chemistry. :

Dou, X., Chen, Z., Liu, Y., Li, Y., Ye, J., Lu, L. (2024) Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia. Life sciences. 344:122564

Germeys, C., Vandoorne, T., Davie, K., Poovathingal, S., Heeren, K., Vermeire, W., Nami, F., Moisse, M., Quaegebeur, A., Sierksma, A., Rué, L., Sicart, A., Eykens, C., De Cock, L., De Strooper, B., Carmeliet, P., Van Damme, P., De Bock, K., Van Den Bosch, L. (2024) Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response. Cell Reports. 43:114719114719

Liu, X., Tang, J., Wang, Z., Zhu, C., Deng, H., Sun, X., Yu, G., Rong, F., Chen, X., Liao, Q., Jia, S., Liu, W., Zha, H., Fan, S., Cai, X., Gui, J.F., Xiao, W. (2024) Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3. Nature communications. 15:35333533

Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967

Fan, S., Wang, J., Yu, G., Rong, F., Zhang, D., Xu, C., Du, J., Li, Z., Ouyang, G., Xiao, W. (2020) TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation. The Journal of biological chemistry. 295(48):16299-16313

Ma, Y., Wu, Y., Xia, Z., Li, J., Li, X., Xu, P., Zhou, X., Xue, M. (2019) Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Frontiers in pharmacology. 10:1356

Hyvarinen, J., Parikka, M., Sormunen, R., Ramet, M., Tryggvason, K., Kivirikko, K.I., Myllyharju, J., and Koivunen, P. (2010) Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. The Journal of biological chemistry. 285(53):42023-42032

van Rooijen, E., Voest, E.E., Logister, I., Korving, J., Schwerte, T., Schulte-Merker, S., Giles, R.H., and van Eeden, F.J. (2009) Zebrafish mutants in the von Hippel-Lindau (VHL) tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. Blood. 113(25):6449-6460

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (21):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2019) Semi-automated association of ENSDARG and ENSDART identifiers with ZFIN genes and transcripts. Semi-automated Curation.

Zebrafish Nomenclature Committee (2018) Nomenclature Data Curation (2018). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.