ZFIN

ZFIN ID: ZDB-GENE-030131-3232

ZFIN ID: ZDB-GENE-030131-3232

CITATIONS (58 total)

Gene Name:	histone deacetylase 6
Gene Symbol:	hdac6

Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R. (2024) ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(9):934-946

Pezzotta, A., Brioschi, L., Carbone, S., Mazzoleni, B., Bontempi, V., Monastra, F., Mauri, L., Marozzi, A., Mione, M., Pistocchi, A., Viani, P. (2023) Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability. International Journal of Molecular Sciences. 24(6):

Pezzotta, A., Gentile, I., Genovese, D., Totaro, M.G., Battaglia, C., Leung, A.Y., Fumagalli, M., Parma, M., Cazzaniga, G., Fazio, G., Alcalay, M., Marozzi, A., Pistocchi, A. (2022) HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis. Pharmacological research. 183:106378

Varga, J.K., Diffley, K., Welker Leng, K.R., Fierke, C.A., Schueler-Furman, O. (2022) Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates. Scientific Reports. 12:1788

Volpatti, J.R., Ghahramani-Seno, M.M., Mansat, M., Sabha, N., Sarikaya, E., Goodman, S.J., Chater-Diehl, E., Celik, A., Pannia, E., Froment, C., Combes-Soia, L., Maani, N., Yuki, K.E., Chicanne, G., Uusküla-Reimand, L., Monis, S., Alvi, S.A., Genetti, C.A., Payrastre, B., Beggs, A.H., Bonnemann, C.G., Muntoni, F., Wilson, M.D., Weksberg, R., Viaud, J., Dowling, J.J. (2022) X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Acta Neuropathologica. 144(3):537-563

Zhuang, M., Scholz, A., Walz, G., Yakulov, T.A. (2022) Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. International Journal of Molecular Sciences. 23(17)

Hosseinzadeh, P., Watson, P.R., Craven, T.W., Li, X., Rettie, S., Pardo-Avila, F., Bera, A.K., Mulligan, V.K., Lu, P., Ford, A.S., Weitzner, B.D., Stewart, L.J., Moyer, A.P., Di Piazza, M., Whalen, J.G., Greisen, P.J., Christianson, D.W., Baker, D. (2021) Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nature communications. 12:3384

Olaoye, O.O., Watson, P.R., Nawar, N., Geletu, M., Sedighi, A., Bukhari, S., Raouf, Y.S., Manaswiyoungkul, P., Erdogan, F., Abdeldayem, A., Cabral, A.D., Hassan, M.M., Toutah, K., Shouksmith, A.E., Gawel, J.M., Israelian, J., Radu, T.B., Kachhiyapatel, N., de Araujo, E.D., Christianson, D.W., Gunning, P.T. (2021) Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of medicinal chemistry. 64(5):2691-2704

Sandrone, G., Cukier, C.D., Zrubek, K., Marchini, M., Vergani, B., Caprini, G., Fossati, G., Steinkühler, C., Stevenazzi, A. (2021) Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. ACS Medicinal Chemistry Letters. 12:1810-1817

Łysyganicz, P.K., Pooranachandran, N., Liu, X., Adamson, K.I., Zielonka, K., Elworthy, S., van Eeden, F.J., Grierson, A.J., Malicki, J.J. (2021) Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Frontiers in cell and developmental biology. 9:676214

Osko, J.D., Christianson, D.W. (2020) Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta crystallographica. Section F, Structural biology communications. 76:428-437

Osko, J.D., Porter, N.J., Narayana Reddy, P.A., Xiao, Y.C., Rokka, J., Jung, M., Hooker, J.M., Salvino, J.M., Christianson, D.W. (2020) Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. Journal of medicinal chemistry. 63:295-308

Pham, T.Q., Robinson, K., Xu, L., Pavlova, M.N., Skapek, S.X., Chen, E.Y. (2020) HDAC6 promotes growth, migration/invasion, and self-renewal of rhabdomyosarcoma. Oncogene. 40(3):578-591

Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69

González-Rojo, S., Lombó, M., Fernández-Díez, C., Herráez, M.P. (2019) Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes. Environmental pollution (Barking, Essex : 1987). 248:368-379

Khazaee, M., Guardian, M.G.E., Aga, D.S., Ng, C.A. (2019) Impacts of sex and exposure duration on gene expression in zebrafish following perfluorooctane sulfonate (PFOS) exposure. Environmental toxicology and chemistry. 39(2):437-449

Lombó, M., Fernández-Díez, C., González-Rojo, S., Herráez, M.P. (2019) Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: from spermatozoa to the progeny. Scientific Reports. 9:18029

Lombó, M., González-Rojo, S., Fernández-Díez, C., Herráez, M.P. (2019) Cardiogenesis impairment promoted by bisphenol A exposure is successfully counteracted by epigallocatechin gallate. Environmental pollution (Barking, Essex : 1987). 246:1008-1019

Vögerl, K., Ong, N., Senger, J., Herp, D., Schmidtkunz, K., Marek, M., Müller, M., Bartel, K., Shaik, T.B., Porter, N.J., Robaa, D., Christianson, D.W., Romier, C., Sippl, W., Jung, M., Bracher, F. (2019) Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 (HDAC6) Inhibitors. Journal of medicinal chemistry. 62(3):1138-1166

Mackwitz, M.K.W., Hamacher, A., Osko, J.D., Held, J., Schöler, A., Christianson, D.W., Kassack, M.U., Hansen, F.K. (2018) Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors. Organic letters. 20(11):3255-3258

Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84

Porter, N.J., Osko, J.D., Diedrich, D., Kurz, T., Hooker, J.M., Hansen, F.K., Christianson, D.W. (2018) Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. Journal of medicinal chemistry. 61:8054-8060

Rothschild, S.C., Lee, H.J., Ingram, S.R., Mohammadi, D.K., Walsh, G.S., Tombes, R.M. (2018) Calcium Signals Act Through Histone Deacetylase to Mediate Pronephric Kidney Morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(6):807-817

Sellmer, A., Stangl, H., Beyer, M., Grünstein, E., Leonhardt, M., Pongratz, H., Eichhorn, E., Elz, S., Striegl, B., Jenei-Lanzl, Z., Dove, S., Straub, R.H., Krämer, O.H., Mahboobi, S. (2018) Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors. Journal of medicinal chemistry. 61:3454-3477

Hai, Y., Shinsky, S.A., Porter, N.J., Christianson, D.W. (2017) Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nature communications. 8:15368

Porter, N.J., Mahendran, A., Breslow, R., Christianson, D.W. (2017) Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 114(51):13459-13464

Zhang, L., Jin, Y., Han, Z., Liu, H., Shi, L., Hua, X., A Doering, J., Tang, S., P Giesy, J., Yu, H. (2017) INTEGRATED IN SILICO AND IN VIVO APPROACHES TO INVESTIGATE EFFECTS OF BDE-99 MEDIATED BY THE NUCLEAR RECEPTORS ON DEVELOPING ZEBRAFISH. Environmental toxicology and chemistry. 37(3):780-787

Brocal, I., White, R.J., Dooley, C.M., Carruthers, S.N., Clark, R., Hall, A., Busch-Nentwich, E.M., Stemple, D.L., Kettleborough, R.N. (2016) Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. BMC Genomics. 17:259

Hai, Y., Christianson, D.W. (2016) Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nature Chemical Biology. 12(9):741-7

Miyake, Y., Keusch, J.J., Wang, L., Saito, M., Hess, D., Wang, X., Melancon, B.J., Helquist, P., Gut, H., Matthias, P. (2016) Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nature Chemical Biology. 12(9):748-54

Pinho, B.R., Reis, S.D., Guedes-Dias, P., Leitão-Rocha, A., Quintas, C., Valentão, P., Andrade, P.B., Santos, M.M., Oliveira, J.M. (2016) Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: therapeutic implications for Parkinson's disease. Pharmacological research. 103:328-39

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Ramanoudjame, L., Rocancourt, C., Lainé, J., Klein, A., Joassard, L., Gartioux, C., Fleury, M., Lyphout, L., Kabashi, E., Ciura, S., Cousin, X., Allamand, V. (2015) Two novel COLVI long chains in zebrafish that are essential for muscle development. Human molecular genetics. 24(23):6624-39

Li, Y., Wang, J., Xie, Y., Liu, S., Tian, Y. (2014) Pattern of change in histone 3 lysine 9 acetylation and histone deacetylases in development of zebrafish embryo. Journal of genetics. 93:539-44

Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Kaluza, D., Kroll, J., Gesierich, S., Yao, T.P., Boon, R.A., Hergenreider, E., Tjwa, M., Rössig, L., Seto, E., Augustin, H.G., Zeiher, A.M., Dimmeler, S., and Urbich, C. (2011) Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. The EMBO journal. 30(20):4142-56

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Additional Citations (19):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of SNP Database Links. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.