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Gene

hdac6

ID
ZDB-GENE-030131-3232
Name
histone deacetylase 6
Symbol
hdac6 Nomenclature History
Previous Names
  • wu:fc31d02
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Enables potassium ion binding activity; tubulin deacetylase activity; and zinc ion binding activity. Acts upstream of or within angiogenesis; hemopoiesis; and protein deacetylation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hdac6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia Alliance ?Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia 300863
Associated With hdac6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001607 Zinc finger, UBP-type
Domain IPR023801 Histone deacetylase domain
Family IPR000286 Histone deacetylase family
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR023696 Ureohydrolase domain superfamily
Homologous_superfamily IPR037138 Histone deacetylase domain superfamily
Domain Details Per Protein
Protein Length Histone deacetylase domain Histone deacetylase domain superfamily Histone deacetylase family Ureohydrolase domain superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, UBP-type
UniProtKB:A7YT55 929
UniProtKB:F8W336 33
UniProtKB:F8W4B7 1081
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations