ZFIN ID: ZDB-GENE-030131-3232
Gene Name: histone deacetylase 6
Gene Symbol: hdac6    Nomenclature History

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Previous Name: wu:fc31d02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits potassium ion binding activity; tubulin deacetylase activity; and zinc ion binding activity. Involved in angiogenesis; hemopoiesis; and protein deacetylation. Orthologous to human HDAC6 (histone deacetylase 6).
Genome Resources: Alliance (1),  Gene:565482 (1),  Ensembl(GRCz11):ENSDARG00000008384 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026686Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18529 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34293 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34294 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hdac6
    1
    CRISPR2-hdac6
    1
    CRISPR3-hdac6
    1
    CRISPR4-hdac6
    1
    MO1-hdac6 N/A 1
    MO2-hdac6 N/A 1
    MO3-hdac6 N/A 1
    MO4-hdac6 N/A 1
    MO5-hdac6 N/A 1
    DISEASE ASSOCIATED WITH hdac6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia 300863
    DISEASE ASSOCIATED WITH hdac6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Molecular Function NOT   acetylspermidine deacetylase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hdac6-201 (1)    Ensembl 3951
    hdac6-202 (1)    Ensembl 418
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hdac6 No data available
    MARKER RELATIONSHIPS
    hdac6 Contained in: [BAC] CH211-150E8 (1)
    hdac6 Contains: [SNP] rs3728138 (1), rs3728139 (1), rs3728140 (1)
    hdac6 Encodes: [EST] fc31d02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009303751 (1)
    Genomic GenBank:BX469901 (1) 180553 nt
    Select Tool
    Polypeptide UniProtKB:F8W4B7 (1) 1081 aa
    Sequence Information (all 15)
    ORTHOLOGY for hdac6 ( Chr: 8 )
    CITATIONS (41)