ZFIN

ZFIN ID: ZDB-GENE-030131-1280

ZFIN ID: ZDB-GENE-030131-1280

CITATIONS (60 total)

Gene Name:	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene Symbol:	pik3r1

Pillai, L., Nesari, V., Danes, D., Balakrishnan, S. (2025) Inhibition of COX2 impairs angiogenesis and causes vascular defects in developing zebrafish embryos. The International journal of developmental biology. :

Velumani, K., Rajan, P.S., Shaik, M.R., Hussain, S.A., Shaik, B., Guru, A., Issac, P.K. (2025) Protective Effect of Artemisinin Against Luperox Induced Oxidative Stress and Insulin Resistance via Pi3k/Akt Pathway in Zebrafish Larvae. Cell biochemistry and biophysics. :

Yan, F., Wang, W., Moossavi, M., Zhu, P., Odell, N., Xu, X. (2025) Deregulated nutrient response in ttntv cardiomyopathy can be repaired via Erk inhibition for cardioprotective effects. Journal of Molecular and Cellular Cardiology. :

Zhu, P., Lavin, A., Xu, X., Lin, X. (2025) ift140-Deficient Zebrafish as a Model for Kidney Cystogenesis and an F0-Based Screen for Genetic Modifiers of Kidney Cysts. Journal of the American Society of Nephrology : JASN. :

De Bortoli, M., Queisser, A., Pham, V.C., Dompmartin, A., Helaers, R., Boutry, S., Claus, C., De Roo, A.K., Hammer, F., Brouillard, P., Abdelilah-Seyfried, S., Boon, L.M., Vikkula, M. (2024) Somatic loss-of-function PIK3R1 and activating non-hotspot PIK3CA mutations associated with Capillary Malformation with Dilated Veins (CMDV). The Journal of investigative dermatology. 144(9):2066-2077.e6

Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007

Pang, M., Yao, H., Bao, K., Xu, R., Xi, R., Peng, R., Zhi, H., Zhang, K., He, R., Du, Y., Su, Y., Liu, X., Ming, D. (2024) Phenolic Glycoside Monomer from Reed Rhizome Inhibits Melanin Production via PI3K-Akt and Ras-Raf-MEK-ERK Pathways. Current Medicinal Chemistry. :

Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401

Xin, S., Zhang, M., Li, P., Wang, L., Zhang, X., Zhang, S., Mu, Z., Lin, H., Li, X., Liu, K. (2024) Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Marine drugs. 22(4):

Zhou, X., Lian, K., Jia, J., Zhao, X., Duan, P., Huang, J., Shi, Y. (2024) Functions of Epimedin C in a zebrafish model of glucocorticoid-induced osteoporosis. Journal of Cellular and Molecular Medicine. 28:e18569e18569

Ding, Y., Wang, M., Bu, H., Li, J., Lin, X., Xu, X. (2022) An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy. Disease models & mechanisms. 16(5):

Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530

Thiagarajan, S.K., Mok, S.Y., Ogawa, S., Parhar, I.S., Tang, P.Y. (2022) Receptor-Mediated AKT/PI3K Signalling and Behavioural Alterations in Zebrafish Larvae Reveal Association between Schizophrenia and Opioid Use Disorder. International Journal of Molecular Sciences. 23(9)

Gong, L., Zhou, H., Wang, C., He, L., Guo, C., Peng, C., Li, Y. (2021) Hepatoprotective effect of Forsythiaside A against acetaminophen-induced liver injury in zebrafish: coupling network pharmacology with biochemical pharmacology. Journal of ethnopharmacology. 271:113890

Mawed, S.A., He, Y., Zhang, J., Mei, J. (2020) Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish. International Journal of Molecular Sciences. 21(4):

Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132

Yu, L., Gong, L., Wang, C., Hu, N., Tang, Y., Zheng, L., Dai, X., Li, Y. (2020) Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. Drug design, development and therapy. 14:1493-1506

Zhao, X., Gong, L., Wang, C., Liu, M., Hu, N., Dai, X., Peng, C., Li, Y. (2020) Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 signaling pathway. Journal of ethnopharmacology. 268:113569

Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307

Ma, Q., Hu, C.T., Yue, J., Luo, Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2019) High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Fish physiology and biochemistry. 46(2):665-679

Mazumder, A.G., Kumari, S., Singh, D. (2019) Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. Epilepsy Research. 157:106207

Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., Li, Y., Peng, C. (2019) Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. 306:66-79

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Tanwar, G., Mazumder, A.G., Bhardwaj, V., Kumari, S., Bharti, R., Yamini, ., Singh, D., Das, P., Purohit, R. (2019) Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Scientific Reports. 9:7904

Junaid, M., Jia, P.P., Tang, Y.M., Xiong, W.X., Huang, H.Y., Strauss, P.R., Li, W.G., Pei, D.S. (2018) Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China. Environmental pollution (Barking, Essex : 1987). 242(Pt B):1939-1949

Zhang, J., Zhang, X., Liu, Y., Su, Z., Dawar, F.U., Dan, H., He, Y., Gui, J.F., Mei, J. (2017) Leucine mediates autophagosome-lysosome fusion and improves sperm motility by activating the PI3K/Akt pathway. Oncotarget. 8:111807-111818

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Gui, J., Greene, C.S., Sullivan, C., Taylor, W., Moore, J.H., Kim, C. (2015) Testing multiple hypotheses through IMP weighted FDR based on a genetic functional network with application to a new zebrafish transcriptome study. BioData mining. 8:17

Blackburn, J.S., Liu, S., Wilder, J.L., Dobrinski, K.P., Lobbardi, R., Moore, F.E., Martinez, S.A., Chen, E.Y., Lee, C., Langenau, D.M. (2014) Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell. 25:366-78

Sasore, T., Kennedy, B. (2014) Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo. PLoS One. 9:e105280

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P. (2012) Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish. Developmental Biology. 365(2):434-444

Nicoli, S., Knyphausen, C.P., Zhu, L.J., Lakshmanan, A., and Lawson, N.D. (2012) miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development. Developmental Cell. 22(2):418-429

Nourizadeh-Lillabadi, R., Lyche, J.L., Almaas, C., Stavik, B., Moe, S.J., Aleksandersen, M., Berg, V., Jakobsen, K.S., Stenseth, N.C., Utne Skåre, J., Alestrøm, P., and Ropstad, E. (2009) Transcriptional Regulation in Liver and Testis Associated with Developmental and Reproductive Effects in Male Zebrafish Exposed to Natural Mixtures of Persistent Organic Pollutants (POP). Journal of toxicology and environmental health. Part A. 72(3):112-130

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Additional Citations (25):

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) Temporary Manual Curation. Manually curated data.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.