PUBLICATION
Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish
- Authors
- Xin, S., Zhang, M., Li, P., Wang, L., Zhang, X., Zhang, S., Mu, Z., Lin, H., Li, X., Liu, K.
- ID
- ZDB-PUB-240427-6
- Date
- 2024
- Source
- Marine drugs 22(4): (Journal)
- Registered Authors
- Keywords
- 4-hydroxyphenylacetic acid, antithrombotic, autophagy, marine-derived fungus
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Fibrinolytic Agents*/pharmacology
- Zebrafish*
- Aquatic Organisms
- Thrombosis/drug therapy
- Biological Products/pharmacology
- Signal Transduction/drug effects
- Phenylacetates*/pharmacology
- Autophagy*/drug effects
- PubMed
- 38667765 Full text @ Mar. Drugs
Citation
Xin, S., Zhang, M., Li, P., Wang, L., Zhang, X., Zhang, S., Mu, Z., Lin, H., Li, X., Liu, K. (2024) Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Marine drugs. 22(4):.
Abstract
Marine natural products are important sources of novel drugs. In this study, we isolated 4-hydroxyphenylacetic acid (HPA) from the marine-derived fungus Emericellopsis maritima Y39-2. The antithrombotic activity and mechanism of HPA were reported for the first time. Using a zebrafish model, we found that HPA had a strong antithrombotic activity because it can significantly increase cardiac erythrocytes, blood flow velocity, and heart rate, reduce caudal thrombus, and reverse the inflammatory response caused by Arachidonic Acid (AA). Further transcriptome analysis and qRT-PCR validation demonstrated that HPA may regulate autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to exert antithrombotic effects.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping