Genomic Feature
ty119
- ID
- ZDB-ALT-980203-1788
- Name
- ty119
- Synonyms
-
- Y119A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 37294015 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 3148 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop at position 929 (1)
- Flanking Sequence
-
CAATGCTTAATCAGCTACATGAGCGCAGAGATAGCTCCACCAGCACAATGAGCTCAGCATATATAAGCCGTCGGTCCTCTGGCATTTCACCTTGCTACTCCAGTCGTCGCTCAAGTGAGGCTTCGCAATTTGGAGTCCGCAACAACAATGTCAGCTCAGCAGACTCCTATGACCCGATCTCCACAGATCTGTCACGTCGTTCCAGTGAAGCAAGCCAATGTGGTGGTACAGGTGGGCTCCCAAGTTTACTAAATCTCACACCAGCTCAACACTACAGTCTTAAGGCGAAATATGCTGCAGCCACTGGGGGTGCACCACCAACACCTCTGCCCAACATGGATCGCATGAGCCTTAAAACTAGAATGGCCATGTACAATGACTCGCAGGACAGTTCAGCACATTTGCACCATGCCCAAGGTGTAGTCAACTCAAGACGCTGCAGCGACACTGGGTACGGTGCCCCTGGCATAATGCCTCATGAAGTTCCGGCCAATCTTCCA
C/T GACGAGCAAGCGATCCTGTTCGTCGTACAACTCTTGACCCACTCTCCTTGCCAAGAGTTCAGCGGTTCAACAGCATCAGCAACATGAACCTATCACGTCTGCCTGCATATGATCGACGTGCTTTCAACATGCAGAACAACACTTGGTCTGATGGAAGCTTGCACCGTCATCCCTTCAGCCAAAGGCCACCTAGCATATCAGAGAACATTTTAATGGAAAATATGGCCACTGATGGAGGAGATCAACAAGGGGATGATTTGGTGCTTCCCGATGACATGGTACAGTACCTCAGGTCCCAGAATGGTAACTCAAATCACGATTCTGGGATTTCTGTCAATGGCGGTCATGCTCTAGAGTTCCATGGTAATATGACCTCCCAACAACAACAGTTCTATGGGCAACGCAGAATGGGCATGGCAAGCATCAATGGAAGTCACGTAGAGCCTGTTCCAGAACAAATAGCTGATCCGCAGGGCATGAACAAAAACAACATGCCTGTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gli2aty119/ty119 | Homozygous | Unknown | Fig. 3  from Hinits et al., 2007 | ||
| gli2aty119/ty119 | Homozygous | ♀+/- ♂+/- | 27 figures from 20 publications | 39 figures from 22 publications | |
| gli2aty119/ty119 (AB) | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | 3 figures from 2 publications | |
| gli2aty119/+ | Heterozygous | Unknown | Fig. 3 from Hinits et al., 2007 | ||
| gli2aty119/+ | Heterozygous | ♀+/- ♂+/- | Fig. 9 from van Eeden et al., 1996 | Fig. 9 from van Eeden et al., 1996 | |
| gli2aty119/+; gli2ai276/+ | Complex | 2 figures from Wang et al., 2013 | |||
| gli2aty119/ty119 + MO1-gli2a | Complex | 3 figures from 2 publications | |||
| gli2aty119/ty119 + MO2-gli2a | Complex | 2 figures from 2 publications | |||
| gli2aty119/ty119; nu15Tg | Complex | ||||
| gli2aty119/ty119 + MO1-gdf6a | Complex | Fig. 4 from Kawakami et al., 2005 |
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Supplemental Information
- Genotyping protocol
- None
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Schwartz, M.S., Schnabl, J., Litz, M.P.H., Baumer, B.S., Barresi, M. (2019) ΔSCOPE: A new method to quantify 3D biological structures and identify differences in zebrafish forebrain development. Developmental Biology. 460(2):115-138
- Maurya, A.K., Ben, J., Zhao, Z., Lee, R.T., Niah, W., Ng, A.S., Iyu, A., Yu, W., Elworthy, S., van Eeden, F.J., and Ingham, P.W. (2013) Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genetics. 9(12):e1003955
- Wang, X., Zhao, Z., Muller, J., Iyu, A., Khng, A.J., Guccione, E., Ruan, Y., and Ingham, P.W. (2013) Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biology Open. 2(11):1203-1213
- Stückemann, T., Wegleiter, T., Stefan, E., Nägele, O., Tarbashevich, K., Böck, G., Raz, E., and Aanstad, P. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development (Cambridge, England). 139(15):2711-2720
- Wiweger, M.I., Zhao, Z., van Merkesteyn, R.J., Roehl, H.H., and Hogendoornm, P.C. (2012) HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas. PLoS One. 7(1):e29734
- Bergeron, S.A., Tyurina, O.V., Miller, E., Bagas, A., and Karlstrom, R.O. (2011) Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development (Cambridge, England). 138(1):75-85
- Lobbardi, R., Lambert, G., Zhao, J., Geisler, R., Kim, H.R., and Rosa, F.M. (2011) Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. Development (Cambridge, England). 138(9):1783-1794
- Schwend, T., Loucks, E.J., and Ahlgren, S.C. (2010) Visualization of gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish. PLoS One. 5(12):e14396
- Mich, J.K., Blaser, H., Thomas, N.A., Firestone, A.J., Yelon, D., Raz, E., and Chen, J.K. (2009) Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology. 328(2):342-354
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